Date
2020-08-29Metadata
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Aufsatz
Induction of protein aggregation and starvation response by tRNA modification defects
Abstract
Posttranscriptional modifications of anticodon loops contribute to the decoding efficiency of tRNAs by supporting codon recognition and loop stability. Consistently, strong synthetic growth defects are observed in yeast strains simultaneously lacking distinct anticodon loop modifications. These phenotypes are accompanied by translational inefficiency of certain mRNAs and disturbed protein homeostasis resulting in accumulation of protein aggregates. Different combinations of anticodon loop modification defects were shown to affect distinct tRNAs but provoke common transcriptional changes that are reminiscent of the cellular response to nutrient starvation. Multiple mechanisms may be involved in mediating inadequate starvation response upon loss of critical tRNA modifications. Recent evidence suggests protein aggregate induction to represent one such trigger.
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Gefördert im Rahmen des Projekts DEALCitation
@article{doi:10.17170/kobra-202011042071,
author={Klassen, Roland and Bruch, Alexander and Schaffrath, Raffael},
title={Induction of protein aggregation and starvation response by tRNA modification defects},
journal={Current Genetics},
year={2020}
}
0500 Oax
0501 Text $btxt$2rdacontent
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1500 1/eng
2050 ##0##http://hdl.handle.net/123456789/12022
3000 Klassen, Roland
3010 Bruch, Alexander
3010 Schaffrath, Raffael
4000 Induction of protein aggregation and starvation response by tRNA modification defects / Klassen, Roland
4030
4060 Online-Ressource
4085 ##0##=u http://nbn-resolving.de/http://hdl.handle.net/123456789/12022=x R
4204 \$dAufsatz
4170
5550 {{Transfer-RNS}}
5550 {{Modifikation <Biologie>}}
5550 {{Aggregation}}
5550 {{Proteine}}
5550 {{Decodierung}}
7136 ##0##http://hdl.handle.net/123456789/12022
<resource xsi:schemaLocation="http://datacite.org/schema/kernel-2.2 http://schema.datacite.org/meta/kernel-2.2/metadata.xsd"> 2020-11-24T12:54:52Z 2020-11-24T12:54:52Z 2020-08-29 doi:10.17170/kobra-202011042071 http://hdl.handle.net/123456789/12022 Gefördert im Rahmen des Projekts DEAL eng Namensnennung 4.0 International http://creativecommons.org/licenses/by/4.0/ tRNA modification protein aggregation decoding starvation response 570 Induction of protein aggregation and starvation response by tRNA modification defects Aufsatz Posttranscriptional modifications of anticodon loops contribute to the decoding efficiency of tRNAs by supporting codon recognition and loop stability. Consistently, strong synthetic growth defects are observed in yeast strains simultaneously lacking distinct anticodon loop modifications. These phenotypes are accompanied by translational inefficiency of certain mRNAs and disturbed protein homeostasis resulting in accumulation of protein aggregates. Different combinations of anticodon loop modification defects were shown to affect distinct tRNAs but provoke common transcriptional changes that are reminiscent of the cellular response to nutrient starvation. Multiple mechanisms may be involved in mediating inadequate starvation response upon loss of critical tRNA modifications. Recent evidence suggests protein aggregate induction to represent one such trigger. open access Klassen, Roland Bruch, Alexander Schaffrath, Raffael doi:10.1007/s00294-020-01103-w Transfer-RNS Modifikation <Biologie> Aggregation Proteine Decodierung publishedVersion EISSN 1432-0983 Issue 6 Current Genetics 1053-1057 Volume 66 false </resource>
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