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dc.date.accessioned2022-10-28T10:52:47Z
dc.date.available2022-10-28T10:52:47Z
dc.date.issued2022-09-16
dc.identifierdoi:10.17170/kobra-202210287052
dc.identifier.urihttp://hdl.handle.net/123456789/14224
dc.description.sponsorshipGefördert durch den Publikationsfonds der Universität Kassel
dc.language.isoeng
dc.rightsNamensnennung-Nicht-kommerziell 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.ddc540
dc.subject.ddc570
dc.titleEffects of Mangosteen Peel Phenolic Compounds on Tilapia Skin Collagen-Based Mineralized Scaffold Propertieseng
dc.typeAufsatz
dcterms.abstractA proper valorization of biological waste sources for an effective conversion into composites for tissue engineering is discussed in this study. Hence, the collagen and the phenolic compound applied in this investigation were extracted from waste sources, respectively, fish industry rejects and the peels of the mangosteen fruit. Porous scaffolds were prepared by combining both components at different compositions and mineralized at different temperatures to evaluate the modifications in the biomimetic formation of apatite. The inclusion of mangosteen extract showed the advantage of increasing the collagen denaturation temperature, improving the stability of its triple helix. Moreover, the extract provided antioxidant activity due to its phenolic composition, as confirmed by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant assays. Mineralization was successfully achieved as indicated by thermogravimetry and scanning electron microscopy. A higher temperature and a lower extract concentration reduced the calcium phosphate deposits. The extract also affected the pore size, particularly at a lower concentration. The X-ray diffraction pattern identified a low degree of crystallization. A high mineralization temperature induced the formation of smaller crystallites ranging from 18.9 to 25.4 nm. Although the deposited hydroxyapatite showed low crystallinity, the scaffolds are suitable for bone tissue applications and may be effective in controlling the resorbability rate in tissue regeneration.eng
dcterms.accessRightsopen access
dcterms.creatorMilan, Eduardo P.
dcterms.creatorBertolo, Mirella Romanelli Vicente
dcterms.creatorMartins, Virginia da Conceição Amaro
dcterms.creatorSobrero, César Enrique
dcterms.creatorPlepis, Ana Maria de Guzzi
dcterms.creatorFuhrmann-Lieker, Thomas
dcterms.creatorHorn, Marilia Marta
dc.relation.doidoi:10.1021/acsomega.2c03266
dc.subject.swdFischeger
dc.subject.swdMangostaneger
dc.subject.swdHautger
dc.subject.swdKollagenger
dc.type.versionpublishedVersion
dcterms.source.identifiereissn:2470-1343
dcterms.source.issueIssue 38
dcterms.source.journalACS Omega
dcterms.source.pageinfo34022-34033
dcterms.source.volumeVolume 7
kup.iskupfalse


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