Datum
2021-02-05Autor
Wang, QiangYildirim, Timur MertSchickhardt, Sonja KatrinŁabuz, GrzegorzKhoramnia, RaminMerz, Patrick R.Son, Hyeck-SooMunro, Donald JohnFriedmann, ElfriedeAuffarth, Gerd UweSchlagwort
510 Mathematik 570 Biowissenschaften, Biologie AlternBiomaterialStabilitätKunststofflinseMetadata
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Quantification of the In Vitro Predisposition to Glistening Formation in One Manufacturer’s Acrylic Intraocular Lenses Made in Different Decades
Zusammenfassung
Introduction
Foldable hydrophobic acrylic intraocular lenses (IOLs) are prone to develop a long-term postoperative material change called glistenings. The aim of this study was to investigate the changes in the predisposition for glistening formation in one type of hydrophobic acrylic IOL material from its introduction to the present day.
Methods
In a laboratory setup, an in vitro model was used to induce glistenings in hydrophobic acrylic IOLs manufactured by one company (Alcon, Fort Worth, TX, USA) in different years: 23 1990s-manufacture hydrophobic acrylic three-piece IOLs (MA30BA/MA60AC) that were explanted in 1996 and 1997, and five of each of the newer AcrySof IOL models (MA60AC, SA60AT, TFNT00 and SN60WF) from 2014 to 2017. Furthermore, five Clareon (SY60WF) IOLs were put through the same accelerated aging procedure. The number of microvacuoles per square millimeter (MV/mm²) was determined in the central part of each IOL optic and compared between the groups.
Results
The mean number of MV was highest in the 1990s-manufacture Alcon acrylic IOLs, with 1289 (± 738) MV/mm². The number decreased to 650 (± 101), 192 (± 105), 175 (± 112) and 47 (± 26) for MA60AC, SA60AT, TFNT00 and SN60WF, respectively. The lowest count was obtained in the Clareon group, with 1 (± 1) MV/mm².
Conclusions
A high number of glistenings was induced in the explanted IOLs from the 1990s. The propensity for glistening formation decreased considerably after that decade and now in current use. Even though in vitro glistening formation in today’s AcrySof material was low, the Clareon material was essentially glistenings-free.
Foldable hydrophobic acrylic intraocular lenses (IOLs) are prone to develop a long-term postoperative material change called glistenings. The aim of this study was to investigate the changes in the predisposition for glistening formation in one type of hydrophobic acrylic IOL material from its introduction to the present day.
Methods
In a laboratory setup, an in vitro model was used to induce glistenings in hydrophobic acrylic IOLs manufactured by one company (Alcon, Fort Worth, TX, USA) in different years: 23 1990s-manufacture hydrophobic acrylic three-piece IOLs (MA30BA/MA60AC) that were explanted in 1996 and 1997, and five of each of the newer AcrySof IOL models (MA60AC, SA60AT, TFNT00 and SN60WF) from 2014 to 2017. Furthermore, five Clareon (SY60WF) IOLs were put through the same accelerated aging procedure. The number of microvacuoles per square millimeter (MV/mm²) was determined in the central part of each IOL optic and compared between the groups.
Results
The mean number of MV was highest in the 1990s-manufacture Alcon acrylic IOLs, with 1289 (± 738) MV/mm². The number decreased to 650 (± 101), 192 (± 105), 175 (± 112) and 47 (± 26) for MA60AC, SA60AT, TFNT00 and SN60WF, respectively. The lowest count was obtained in the Clareon group, with 1 (± 1) MV/mm².
Conclusions
A high number of glistenings was induced in the explanted IOLs from the 1990s. The propensity for glistening formation decreased considerably after that decade and now in current use. Even though in vitro glistening formation in today’s AcrySof material was low, the Clareon material was essentially glistenings-free.
Zitierform
In: Ophthalmology and Therapy Volume 10 / Issue 1 (2021-02-05) , S. 165-174 ; eissn:2193-6528Zitieren
@article{doi:10.17170/kobra-2024082910752,
author={Wang, Qiang and Yildirim, Timur Mert and Schickhardt, Sonja Katrin and Łabuz, Grzegorz and Khoramnia, Ramin and Merz, Patrick R. and Son, Hyeck-Soo and Munro, Donald John and Friedmann, Elfriede and Auffarth, Gerd Uwe},
title={Quantification of the In Vitro Predisposition to Glistening Formation in One Manufacturer’s Acrylic Intraocular Lenses Made in Different Decades},
journal={Ophthalmology and Therapy},
year={2021}
}
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2024-09-11T10:33:52Z 2024-09-11T10:33:52Z 2021-02-05 doi:10.17170/kobra-2024082910752 http://hdl.handle.net/123456789/16035 eng Namensnennung-Nicht-kommerziell 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ accelerated aging biomaterial stability glistenings IOL material history IOL pathology 510 570 Quantification of the In Vitro Predisposition to Glistening Formation in One Manufacturer’s Acrylic Intraocular Lenses Made in Different Decades Aufsatz Introduction Foldable hydrophobic acrylic intraocular lenses (IOLs) are prone to develop a long-term postoperative material change called glistenings. The aim of this study was to investigate the changes in the predisposition for glistening formation in one type of hydrophobic acrylic IOL material from its introduction to the present day. Methods In a laboratory setup, an in vitro model was used to induce glistenings in hydrophobic acrylic IOLs manufactured by one company (Alcon, Fort Worth, TX, USA) in different years: 23 1990s-manufacture hydrophobic acrylic three-piece IOLs (MA30BA/MA60AC) that were explanted in 1996 and 1997, and five of each of the newer AcrySof IOL models (MA60AC, SA60AT, TFNT00 and SN60WF) from 2014 to 2017. Furthermore, five Clareon (SY60WF) IOLs were put through the same accelerated aging procedure. The number of microvacuoles per square millimeter (MV/mm²) was determined in the central part of each IOL optic and compared between the groups. Results The mean number of MV was highest in the 1990s-manufacture Alcon acrylic IOLs, with 1289 (± 738) MV/mm². The number decreased to 650 (± 101), 192 (± 105), 175 (± 112) and 47 (± 26) for MA60AC, SA60AT, TFNT00 and SN60WF, respectively. The lowest count was obtained in the Clareon group, with 1 (± 1) MV/mm². Conclusions A high number of glistenings was induced in the explanted IOLs from the 1990s. The propensity for glistening formation decreased considerably after that decade and now in current use. Even though in vitro glistening formation in today’s AcrySof material was low, the Clareon material was essentially glistenings-free. open access Wang, Qiang Yildirim, Timur Mert Schickhardt, Sonja Katrin Łabuz, Grzegorz Khoramnia, Ramin Merz, Patrick R. Son, Hyeck-Soo Munro, Donald John Friedmann, Elfriede Auffarth, Gerd Uwe doi:10.1007/s40123-020-00329-8 Altern Biomaterial Stabilität Kunststofflinse publishedVersion eissn:2193-6528 Issue 1 Ophthalmology and Therapy 165-174 Volume 10 false
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