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Dissertation
Functional characterization of disease-associated mutations in type I cGMP-dependent protein kinase
(2022-08)
Cardiovascular diseases are the leading cause of death worldwide, and while mainly associated with behavioral risk factors, they can also be linked to genetic disorders. The cGMP-dependent protein kinase type I (PKG I) plays a pivotal role in the homeostasis of the vasculature by mediating NO/cGMP-dependent relaxation of vascular smooth muscle cells. A recently described genetic risk factor associated with PKG I results in heritable thoracic aortic aneurysms and dissections (TAAD). Although PKG isoforms Iα and Iβ ...
Dissertation
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Magnetic Textures and Magnetization Reversal Processes in Arrays of Ferromagnetic and Exchange-Biased Hollow Hemispheres
(2022)
The main objective of this thesis is to investigate hemispherical caps prepared by thin film deposition of magnetic material compositions on top of nano- and micrometer sized silica spheres. When compared to flat magnetic discs, these microcaps differ in their magnetic properties due to the curved and therefore three-dimensional shape. However, under certain conditions, both microstructures have previously been proven to express the famous magnetic vortex texture because of the confinement into a circular shape. ...
Dissertation
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Electronic Theory of the Magnetic Order, Anisotropy and Reversal Processes in Rolled-Up Stripes and Thin Films
(2022)
A comprehensive multiscale approach consisting of a combination of state of the art, first principles quantum theory and the flexible statistical methodologies of complex systems is applied in order to achieve a detailed microscopic understanding of the magnetic properties of rolled-up transition-metal [TM] ultrathin films and stripes. A quantum electronic investigations of the effective interactions between the local magnetic moments is performed as a function of composition and rolling radius R including the limit ...
Dissertation
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Pollen Metabarcoding: Theory and Application
(2022-01)
Der vom Menschen verursachte Verlust der biologischen Vielfalt bedroht die Versorgungssicherheit durch Ökosystemleistungen, wie beispielsweise Bestäubung. Da unser Überleben als Spezies hiervon abhängt, ist es notwendig, unser Wissen über die Biodiversität in beschleunigter Weise zu erweitern, um dieser Bedrohung zu begegnen. Im Gegensatz zu dem Barcoding, bei welchem ein unbestimmter Organismus mit Hilfe eines Teils seiner DNS durch Abgleich mit einer Referenzdatenbank bestimmt wird, handelt es sich beim Metabarcoding ...
Dissertation
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Optimal control of a rate-independent system constrained to parameterized balanced viscosity solutions
(2022)
In this dissertation, we analyze an optimal control problem governed by a rate-independent system in an abstract infinite-dimensional setting. The rate-independent system is characterized by a nonconvex stored energy functional, which depends on time via a time-dependent external loading, and by a convex dissipation potential, which is assumed to be bounded and positively homogeneous of degree one.
The optimal control problem uses the external load as control variable and is constrained to normalized ...
Dissertation
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Development of a Preconditioning Scheme for Real Gases using Asymptotic Expansions
(2022)
Bei der Beschreibung von Strömungen wird klassischerweise zwischen inkompressiblen und kompressiblen Bereichen unterschieden. Während inkompressible Strömungen durch ein divergenzfreies Geschwindigkeitsfeld charakterisiert werden, sind kompressible Strömungsfelder durch Expansionsfächer, Kontaktunstetigkeiten und Stoßwellen gekennzeichnet. Die beiden Bereiche werden damit durch stark unterschiedliche Systeme partieller Differentialgleichungen beschrieben. Diese Unterscheidung zeigt sich auch in der numerischen ...