The present study aims to evaluate the capability of the Tropical Rainfall Measurement Mission (TRMM), Multi-satellite Precipitation Analysis (TMPA), version 7 (TRMM-3B42-V7) precipitation product to estimate appropriate precipitation rates in the Upper Indus Basin (UIB) by analyzing the dependency of the estimates’ accuracies on the time scale. To that avail, various statistical analyses and comparison of Multisatellite Precipitation Analysis (TMPA) products with gauge measurements in the UIB are carried out. The ...

Spindly was originally identified as a specific regulator of Dynein activity at the kinetochore. In early prometaphase, Spindly recruits the Dynein/Dynactin complex, promoting the establishment of stable kinetochore-microtubule interactions and progression into anaphase. While details of Spindly function in mitosis have been worked out in cultured human cells and in the C. elegans zygote, the function of Spindly within the context of an organism has not yet been addressed. Here, we present loss- and gain-of-function ...

Although retail investors’ interest in sustainable investment is constantly increasing, German credit unions and co-operative banks offer few sustainable financial products. The purpose of the study is to explore the current gap between supply and demand of sustainable financial investments in German retail banking from a financial advisor’s point of view. We use qualitative analysis of interviews with financial advisors based on a Grounded Theory approach with the aim to identify the key causation in the cause-effect ...

The protein phosphatase Sit4 has been shown to be required for lipogenesis and resistance against the acetyl-CoA carboxylase inhibitor soraphen A. Since Sit4 is also required for biosynthesis of Elongator dependent tRNA modifications such as 5-methoxycarbonylmethyluridine (mcm5U), we investigated the relevance of tRNA modifications in lipogenesis and soraphen A response. While sit4 and Elongator (elp3) mutants copy defects in mcm5U formation and stress sensitivity, they do not share soraphen A sensitivity and low ...

Static and dynamic properties of InP-based 1.55 µm quantum dot (QD) lasers were investigated. Due to the reduced size inhomogeneity and a high dot density of the newest generation of 1.55 µm QD gain materials, ridge waveguide lasers (RWG) exhibit improved temperature stability and record-high modulation characteristics. Detailed results are shown for the temperature dependence of static properties including threshold current, voltage-current characteristics, external differential efficiency and emission wavelength. ...

Transfer RNA (tRNA) from all domains of life contains multiple modified nucleosides, the functions of which remain incompletely understood. Genetic interactions between tRNA modification genes in Saccharomyces cerevisiae suggest that different tRNA modifications collaborate to maintain translational efficiency. Here we characterize such collaborative functions in the ochre suppressor tRNA SUP4. We quantified ochre read-through efficiency in mutants lacking either of the 7 known modifications in the extended anticodon ...

In many regions of the world, traditional and local ecological knowledge is still important today for coping with environmental challenges. This study explored the relevance of such knowledge for predicting and coping with harsh winter conditions (dzud) in a remote area of western Mongolia, where government support to disaster-affected herders is restricted by weak infrastructure. Structured face-to-face interviews were held in 50 households (HHs), addressing aspects of livestock possession and management as well as ...

Entanglement generation can be robust against certain types of noise in approaches that deliberately incorporate dissipation into the system dynamics. The presence of additional dissipation channels may, however, limit fidelity and speed of the process. Here we show how quantum optimal control techniques can be used to both speed up the entanglement generation and increase the fidelity in a realistic setup, whilst respecting typical experimental limitations. For the example of entangling two trapped ion qubits (Lin ...

Self-generation of knowledge can activate deeper cognitive processing and improve long-term retention compared to the passive reception of information. It plays a distinctive role within the concept of inquiry-based learning, which is an activity-oriented, student-centered collaborative learning approach in which students become actively involved in knowledge construction by following an idealized hypothetico-deductive method. This approach allows students to not only acquire content knowledge, but also an understanding ...

The Fusarium solani species complex (FSSC) has been studied intensively but its association with legumes, particularly under European agro-climatic conditions, is still poorly understood. In the present study, we investigated phylogenetic relationships and aggressiveness of 79 isolates of the FSSC collected from pea, subterranean clover, white clover and winter vetch grown under diverse agro-climatic and soil conditions within Temperate and Mediterranean Europe. The isolates were characterized by sequencing tef1 and ...