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A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A
(2019-04-20)
Kinases regulate multiple and diverse signaling pathways and misregulation is implicated in a multitude of diseases. Although significant efforts have been put forth to develop kinase-specific inhibitors, specificity remains a challenge. As an alternative to catalytic inhibition, allosteric inhibitors can target areas on the surface of an enzyme, thereby providing additional target diversity. Using cAMP-dependent protein kinase A (PKA) as a model system, we sought to develop a hydrocarbon-stapled peptide targeting ...
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Meshing highly regular structures: The case of super carbon nanotubes of arbitrary order
(2015)
Mesh generation is an important step inmany numerical methods.We present the “HierarchicalGraphMeshing” (HGM)method as a novel approach to mesh generation, based on algebraic graph theory.The HGM method can be used to systematically construct configurations exhibiting multiple hierarchies and complex symmetry characteristics. The hierarchical description of structures provided by the HGM method can be exploited to increase the efficiency of multiscale and multigrid methods. In this paper, the HGM method is employed ...
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Development of 18 Polymorphic Microsatellite Markers for Vinca minor (Apocynaceae) via 454 Pyrosequencing
(2015)
• Premise of the study: Polymorphic microsatellite markers were developed in Vinca minor (Apocynaceae) to evaluate the level of clonality, population structure, and genetic diversity of the species within its native and introduced range.
• Methods and Results: A total of 1371 microsatellites were found in 43,565 reads from 454 pyrosequencing of genomic V. minor DNA. Additional microsatellite loci were mined from publicly available cDNA sequences. After several rounds of screening, 18 primer pairs flanking di-, tri-, ...
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Loss of Anticodon Wobble Uridine Modifications Affects tRNALys Function and Protein Levels in Saccharomyces cerevisiae
(2015)
In eukaryotes, wobble uridines in the anticodons of tRNALysUUU, tRNAGluUUC and tRNAGlnUUG are modified to 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm5s2U). While mutations in subunits of the Elongator complex (Elp1-Elp6), which disable mcm5 side chain formation, or removal of components of the thiolation pathway (Ncs2/Ncs6, Urm1, Uba4) are individually tolerated, the combination of both modification defects has been reported to have lethal effects on Saccharomyces cerevisiae. Contrary to such absolute requirement ...
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Detecting ultrafast interatomic electronic processes in media by fluorescence
(In: New journal of physics. - London : IOP, 2014, 16, 102002, 1-9, 2014)
Interatomic coulombic decay (ICD), a radiationless transition in weakly bonded systems, such as solutes or van der Waals bound aggregates, is an effective source for electrons of low kinetic energy. So far, the ICD processes could only be probed in ultra-high vacuum by using electron and/or ion spectroscopy. Here we show that resonant ICD processes can also be detected by measuring the subsequently emitted characteristic fluorescence radiation, which makes their study in dense media possible.
Aufsatz
Asymptotic model for shape resonance control of diatomics by intense non-resonant light: universality in the single-channel approximation
(2015)
Non-resonant light interacting with diatomics via the polarizability anisotropy couples different
rotational states and may lead to strong hybridization of the motion. The modification of shape
resonances and low-energy scattering states due to this interaction can be fully captured by an
asymptotic model, based on the long-range properties of the scattering (Crubellier et al 2015 New J.
Phys. 17 045020). Remarkably, the properties of the field-dressed shape resonances in this asymptotic
multi-channel description ...
Aufsatz
Asymptotic model for shape resonance control of diatomics by intense non-resonant light
(2015)
We derive a universal model for atom pairs interacting with non-resonant light via the polarizability
anisotropy, based on the long range properties of the scattering. The corresponding dynamics can be
obtained using a nodal line technique to solve the asymptotic Schrödinger equation. It consists of
imposing physical boundary conditions at long range and vanishing the wavefunction at a position
separating the inner zone and the asymptotic region. We show that nodal lines which depend on the
intensity of the ...
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Femtosecond wavepacket interferometry using the rotational dynamics of a trapped cold molecular ion
(2015)
A Ramsey-type interferometer is suggested, employing a cold trapped ion and two time-delayed offresonant
femtosecond laser pulses. The laser light couples to the molecular polarization anisotropy,
inducing rotational wavepacket dynamics. An interferogram is obtained from the delay dependent
populations of the final field-free rotational states. Current experimental capabilities for cooling and
preparation of the initial state are found to yield an interferogram visibility of more than 80%. The
interferograms can ...
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Optical amplification and stability of spiroquaterphenyl compounds and blends
(2015)
In this contribution, we present a systematic investigation on a series of piroquaterphenyl compounds optimised for solid state lasing in the near ultraviolet (UV). Amplified spontaneous emission (ASE) thresholds in the order of 1 μJ/cm2 are obtained in neat (undiluted) films and blends, with emission peaks at 390 1 nm for unsubstituted and meta-substituted quaterphenyls and 400 4 nm for para-ether substituted quaterphenyls. Mixing with a transparent matrix retains a low threshold, shifts the emission to lower ...
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Effects of changing water availability on land use in irrigated mountain oases of Al Jabal Al Akhdar, northern Oman
(2014)
In Oman, during the last three decades, agricultural water use and groundwater extraction has dramatically increased to meet the needs of a rapidly growing population and major changes in lifestyle. This has triggered agricultural land-use changes which have been poorly investigated. In view of this our study aimed at analysing patterns of shortterm land-use changes (2007-2009) in the five irrigated mountain oases of Ash Sharayjah, Al’Ayn, Al’Aqr, Qasha’ and Masayrat ar Ruwajah situated in the northern Oman Hajar ...