Suche
Anzeige der Dokumente 691-700 von 1070
Aufsatz
A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A
(2019-04-20)
Kinases regulate multiple and diverse signaling pathways and misregulation is implicated in a multitude of diseases. Although significant efforts have been put forth to develop kinase-specific inhibitors, specificity remains a challenge. As an alternative to catalytic inhibition, allosteric inhibitors can target areas on the surface of an enzyme, thereby providing additional target diversity. Using cAMP-dependent protein kinase A (PKA) as a model system, we sought to develop a hydrocarbon-stapled peptide targeting ...
Aufsatz
Mineralisation of distinct biogas digestate qualities directly after application to soil
(2020-11-02)
Biogas is an important energy source produced by the anaerobic fermentation of raw faecal slurries and plant residues. Separation of the total digestate increases the fertilizer quality of the liquid fraction and the carbon sequestration potential of the solid fraction. A 12-day incubation study was carried out to investigate the relationships between the chemical composition of different digestate qualities and the immediate response of soil microbial activity and biomass indices. The highest cumulative (Σ) CO2-C ...
Aufsatz
Combined leaching and plant uptake simulations of PFOA and PFOS under field conditions
(2020-08-31)
Per- and polyfluoroalkyl substances (PFASs) are used in industrial production and manufacturing but were repeatedly detected in agricultural soils and therefore in cash crops in recent years. Dissipation of perfluoroalkyl acids (PFAAs), a sub-group of PFASs, in the environment was rather attributed to the formation of non-extractable residues (NER) than to degradation or transformation. Currently, there are no models describing the fate of PFAAs in the soil-plant continuum under field conditions, which hampers an ...
Aufsatz
Are criminals better lie detectors? Investigating offenders' abilities in the context of deception detection
(2020-10-24)
The present research examined lie detection abilities of a rarely investigated group, namely offenders. Results of the studies conducted thus far indicated a better performance of offenders compared to non‐offenders when discriminating between true and false messages. With two new studies, we aimed at replicating offenders' superior abilities in the context of deception detection. Results of Study 1 (N = 76 males), in contrast, revealed that offenders were significantly worse at accurately classifying true and false ...
Aufsatz
Chalcogen‐Transfer Rearrangement: Exploring Inter‐ versus Intramolecular P−P Bond Activation
(2020-07-17)
tert‐Butyl‐substituted diphospha[2]ferrocenophane has been used as a stereochemically confined diphosphane to explore the addition of O, S, Se and Te. Although the diphosphanylchalcogane has been obtained for tellurium, all other chalcogens give diphosphane monochalcogenides. The latter transform via chalcogen‐transfer rearrangement to the corresponding diphosphanylchalcoganes upon heating. The kinetics of this rearrangement has been followed with NMR spectroscopy supported by DFT calculations. Intermediates during ...
Aufsatz
Meshing highly regular structures: The case of super carbon nanotubes of arbitrary order
(2015)
Mesh generation is an important step inmany numerical methods.We present the “HierarchicalGraphMeshing” (HGM)method as a novel approach to mesh generation, based on algebraic graph theory.The HGM method can be used to systematically construct configurations exhibiting multiple hierarchies and complex symmetry characteristics. The hierarchical description of structures provided by the HGM method can be exploited to increase the efficiency of multiscale and multigrid methods. In this paper, the HGM method is employed ...
Aufsatz
Modelling stress‐state dependent nonlocal damage and failure of ductile metals
(2021-01-25)
Damage and failure of ductile metals is highly influenced by the stress state. In fact, void growth takes place under hydrostatic tensile loading and void coalescence leads eventually to ductile failure. A completely different damage mechanism occurs for shear dominated loading that results in void elongation within a narrow shear band. In order to account for both failure mechanisms, a stress state dependent damage model is proposed. The model is based on a continuum damage mechanics approach, whereby nonlinear ...
Aufsatz
Spontaneous inferential processing while reading interleaved expository texts enables learners to discover the underlying regularities
(2020-11-05)
Recent studies on text sequencing found learning advantages of interleaving over blocking in terms of high‐level inferences. We conducted a 2 × 2 × 2 mixed factorial experiment with college students (n = 117) by manipulating text sequence (interleaved vs. blocked) and self‐questioning activity while reading (spontaneous vs. prompted) between subjects and testing delay (immediately vs. 1‐week delay) within subjects. Results revealed that students are spontaneously engaged in self‐questioning and inferential processing ...
Aufsatz
Development of 18 Polymorphic Microsatellite Markers for Vinca minor (Apocynaceae) via 454 Pyrosequencing
(2015)
• Premise of the study: Polymorphic microsatellite markers were developed in Vinca minor (Apocynaceae) to evaluate the level of clonality, population structure, and genetic diversity of the species within its native and introduced range.
• Methods and Results: A total of 1371 microsatellites were found in 43,565 reads from 454 pyrosequencing of genomic V. minor DNA. Additional microsatellite loci were mined from publicly available cDNA sequences. After several rounds of screening, 18 primer pairs flanking di-, tri-, ...
Aufsatz
Loss of Anticodon Wobble Uridine Modifications Affects tRNALys Function and Protein Levels in Saccharomyces cerevisiae
(2015)
In eukaryotes, wobble uridines in the anticodons of tRNALysUUU, tRNAGluUUC and tRNAGlnUUG are modified to 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm5s2U). While mutations in subunits of the Elongator complex (Elp1-Elp6), which disable mcm5 side chain formation, or removal of components of the thiolation pathway (Ncs2/Ncs6, Urm1, Uba4) are individually tolerated, the combination of both modification defects has been reported to have lethal effects on Saccharomyces cerevisiae. Contrary to such absolute requirement ...