Aufsatz
Artikel (Publikationen im Open Access gefördert durch die UB)
Fat-containing cells are eliminated during Dictyostelium development
Zusammenfassung
Triacylglycerol is a universal storage molecule for metabolic energy in living organisms. However, Dictyostelium amoebae, that have accumulated storage fat from added fatty acids do not progress through the starvation period preceding the development of the durable spore. Mutants deficient in genes of fat metabolism, such as fcsA, encoding a fatty acid activating enzyme, or dgat1 and dgat2, specifying proteins that synthesize triacylglycerol, strongly increase their chances to contribute to the spore fraction of the developing fruiting body, but lose the ability to produce storage fat efficiently. Dictyostelium seipin, an orthologue of a human protein that in patients causes the complete loss of adipose tissue when mutated, does not quantitatively affect fat storage in the amoeba. Dictyostelium seiP knockout mutants have lipid droplets that are enlarged in size but reduced in number. These mutants are as vulnerable as the wild type when exposed to fatty acids during their vegetative growth phase, and do not efficiently enter the spore head in Dictyostelium development.
Zitierform
In: Biology Open. - Cambridge : Company of Biologists, 2017, 6, 1294-1304Förderhinweis
Gefördert durch den Publikationsfonds der Universität KasselSammlung(en)
Publikationen (Fachgebiet Zellbiologie)Artikel (Publikationen im Open Access gefördert durch die UB)
Zitieren
@article{urn:nbn:de:hebis:34-2018013154278,
author={Kornke, Jessica Maria and Maniak, Markus},
title={Fat-containing cells are eliminated during Dictyostelium development},
year={2017}
}
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2018-01-31T14:39:46Z 2018-01-31T14:39:46Z 2017-09-15 2046-6390 urn:nbn:de:hebis:34-2018013154278 http://hdl.handle.net/123456789/2018013154278 Gefördert durch den Publikationsfonds der Universität Kassel eng Urheberrechtlich geschützt https://rightsstatements.org/page/InC/1.0/ Fatty acid metabolism Fat storage Lipid droplets Development Seipin Dictyostelium discoideum 570 Fat-containing cells are eliminated during Dictyostelium development Aufsatz Triacylglycerol is a universal storage molecule for metabolic energy in living organisms. However, Dictyostelium amoebae, that have accumulated storage fat from added fatty acids do not progress through the starvation period preceding the development of the durable spore. Mutants deficient in genes of fat metabolism, such as fcsA, encoding a fatty acid activating enzyme, or dgat1 and dgat2, specifying proteins that synthesize triacylglycerol, strongly increase their chances to contribute to the spore fraction of the developing fruiting body, but lose the ability to produce storage fat efficiently. Dictyostelium seipin, an orthologue of a human protein that in patients causes the complete loss of adipose tissue when mutated, does not quantitatively affect fat storage in the amoeba. Dictyostelium seiP knockout mutants have lipid droplets that are enlarged in size but reduced in number. These mutants are as vulnerable as the wild type when exposed to fatty acids during their vegetative growth phase, and do not efficiently enter the spore head in Dictyostelium development. open access In: Biology Open. - Cambridge : Company of Biologists, 2017, 6, 1294-1304 Kornke, Jessica Maria Maniak, Markus doi:10.1242/bio.025478
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