Quantification of the In Vitro Predisposition to Glistening Formation in One Manufacturer’s Acrylic Intraocular Lenses Made in Different Decades

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dc.date.accessioned2024-09-11T10:33:52Z
dc.date.available2024-09-11T10:33:52Z
dc.date.issued2021-02-05
dc.identifierdoi:10.17170/kobra-2024082910752
dc.identifier.urihttp://hdl.handle.net/123456789/16035
dc.language.isoeng
dc.relation.doidoi:10.1007/s40123-020-00329-8
dc.rightsNamensnennung-Nicht-kommerziell 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectaccelerated agingeng
dc.subjectbiomaterial stabilityeng
dc.subjectglisteningseng
dc.subjectIOL material historyeng
dc.subjectIOL pathologyeng
dc.subject.ddc510
dc.subject.ddc570
dc.subject.swdAlternger
dc.subject.swdBiomaterialger
dc.subject.swdStabilitätger
dc.subject.swdKunststofflinseger
dc.titleQuantification of the In Vitro Predisposition to Glistening Formation in One Manufacturer’s Acrylic Intraocular Lenses Made in Different Decadeseng
dc.typeAufsatz
dc.type.versionpublishedVersion
dcterms.abstractIntroduction Foldable hydrophobic acrylic intraocular lenses (IOLs) are prone to develop a long-term postoperative material change called glistenings. The aim of this study was to investigate the changes in the predisposition for glistening formation in one type of hydrophobic acrylic IOL material from its introduction to the present day. Methods In a laboratory setup, an in vitro model was used to induce glistenings in hydrophobic acrylic IOLs manufactured by one company (Alcon, Fort Worth, TX, USA) in different years: 23 1990s-manufacture hydrophobic acrylic three-piece IOLs (MA30BA/MA60AC) that were explanted in 1996 and 1997, and five of each of the newer AcrySof IOL models (MA60AC, SA60AT, TFNT00 and SN60WF) from 2014 to 2017. Furthermore, five Clareon (SY60WF) IOLs were put through the same accelerated aging procedure. The number of microvacuoles per square millimeter (MV/mm²) was determined in the central part of each IOL optic and compared between the groups. Results The mean number of MV was highest in the 1990s-manufacture Alcon acrylic IOLs, with 1289 (± 738) MV/mm². The number decreased to 650 (± 101), 192 (± 105), 175 (± 112) and 47 (± 26) for MA60AC, SA60AT, TFNT00 and SN60WF, respectively. The lowest count was obtained in the Clareon group, with 1 (± 1) MV/mm². Conclusions A high number of glistenings was induced in the explanted IOLs from the 1990s. The propensity for glistening formation decreased considerably after that decade and now in current use. Even though in vitro glistening formation in today’s AcrySof material was low, the Clareon material was essentially glistenings-free.eng
dcterms.accessRightsopen access
dcterms.creatorWang, Qiang
dcterms.creatorYildirim, Timur Mert
dcterms.creatorSchickhardt, Sonja Katrin
dcterms.creatorŁabuz, Grzegorz
dcterms.creatorKhoramnia, Ramin
dcterms.creatorMerz, Patrick R.
dcterms.creatorSon, Hyeck-Soo
dcterms.creatorMunro, Donald John
dcterms.creatorFriedmann, Elfriede
dcterms.creatorAuffarth, Gerd Uwe
dcterms.source.identifiereissn:2193-6528
dcterms.source.issueIssue 1
dcterms.source.journalOphthalmology and Therapyeng
dcterms.source.pageinfo165-174
dcterms.source.volumeVolume 10
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