An insight into the runs of homozygosity distribution and breed differentiation in Mangalitsa pigs

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dc.date.accessioned2022-11-07T13:55:31Z
dc.date.available2022-11-07T13:55:31Z
dc.date.issued2022-10-18
dc.description.sponsorshipGefördert durch den Publikationsfonds der Universität Kasselger
dc.identifierdoi:10.17170/kobra-202211077074
dc.identifier.urihttp://hdl.handle.net/123456789/14235
dc.language.isoeng
dc.relation.doidoi:10.3389/fgene.2022.909986
dc.rightsNamensnennung 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMangalitsa pigeng
dc.subjectROH islandseng
dc.subjectgenetic diversityeng
dc.subjectselection signatureseng
dc.subjectruns of homozygosityeng
dc.subject.ddc630
dc.subject.ddc590
dc.subject.swdMangalica-Schweinger
dc.subject.swdSchweinezuchtger
dc.subject.swdHomozygotieger
dc.subject.swdGenetische Variabilitätger
dc.titleAn insight into the runs of homozygosity distribution and breed differentiation in Mangalitsa pigseng
dc.typeAufsatz
dc.type.versionpublishedVersion
dcterms.abstractMangalitsa pigs exhibit three distinct coat color patterns based on which they are described as Red, Blond, and Swallow-bellied. The current study investigated genome-wide diversity and selection signatures in the three breeds using fixation index, runs of homozygosity and population structure analyses. The analyses were originally based on quality-controlled data on 77 Mangalitsa animals from Germany, including 23 Blond, 30 Swallow-bellied and 24 Red Mangalitsa genotyped with a customized version of the ProcineSNP60 v2 Genotyping Bead Chip. Also, 20 Hungarian Mangalitsa genotypes were included as outgroup data for comparison. Estimates of observed heterozygosity were 0.27, 0.28, and 0.29, and inbreeding coefficients estimated based on runs of homozygosity were 24.11%, 20.82%, and 16.34% for Blond, Swallow-bellied and Red Mangalitsa, respectively. ROH islands were detected in all breeds, however, none of these were shared amongst them. The KIF16B gene previously reported to play a role in synaptic signaling was found in a ROH island (SSC17: 16–26) in Swallow-bellied Mangalitsa. The same gene was found to harbor a significantly differentiated SNP (MARC0032380) while contrasting either Blond or Red to Swallow-belied Mangalitsa. In the Red Mangalitsa, some ROH islands were associated with genes that play a role in meat quality traits, i.e., ABCA12, VIL1, PLSCR5, and USP37. Our population structure analysis highlighted a separation of the three breeds, but also showed the closest relatedness between Red and Blond Mangalitsa pigs. Findings of this study improve our understanding of the diversity in the three breeds of Mangalitsa pigs.eng
dcterms.accessRightsopen access
dcterms.creatorAddo, Sowah
dcterms.creatorJung, Lisa
dcterms.source.articlenumber909986
dcterms.source.identifiereissn:1664-8021
dcterms.source.journalFrontiers in Geneticseng
dcterms.source.volumeVol 13
kup.iskupfalse

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