Integrative-interpersonal dynamic therapy for poststroke depression (INID): study protocol of a randomised controlled pilot trial

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dc.date.accessioned2023-08-25T04:44:18Z
dc.date.available2023-08-25T04:44:18Z
dc.date.issued2023-08-08
dc.description.sponsorshipGefördert durch den Publikationsfonds der Universität Kassel
dc.identifierdoi:10.17170/kobra-202308188639
dc.identifier.urihttp://hdl.handle.net/123456789/15028
dc.language.isoeng
dc.relation.doidoi:10.1136/bmjopen-2023-077656
dc.rightsNamensnennung-Nicht-kommerziell 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.ddc150
dc.subject.ddc610
dc.subject.swdMedizinger
dc.subject.swdPsychologieger
dc.subject.swdSchlaganfallger
dc.subject.swdDepressionger
dc.subject.swdKontrollierte klinische Studieger
dc.titleIntegrative-interpersonal dynamic therapy for poststroke depression (INID): study protocol of a randomised controlled pilot trialeng
dc.typeAufsatz
dc.type.versionpublishedVersion
dcterms.abstractIntroduction Depression is the most frequent psychiatric disorder following stroke, affecting about one-third of stroke survivors. Patients experience poorer recovery, lower quality of life and higher mortality compared with stroke survivors without depression. Despite these well-known malign consequences, poststroke depression (PSD) is regarded underdiagnosed and undertreated. Evidence of beneficial effects of psychotherapy to treat PSD remains scarce and inconclusive and is limited by heterogeneity in design, content and timing of the intervention. This pilot study aims to assess the feasibility of a newly developed integrative-interpersonal dynamic PSD intervention in an outpatient setting and provide a first estimation of the potential effect size as basis for the sample size estimation for a subsequent definite trial. Method and analysis Patients will be recruited from two German stroke units. After discharge from inpatient rehabilitation, depressed stroke survivors will be randomised to short-term psychotherapy (12 weeks, ≤16 sessions) or enhanced treatment as usual. The manualised psychotherapy integrates key features of the Unified Psychodynamic and Cognitive-Behavioural Unified Protocol for emotional disorders and was adapted for PSD. Primary endpoints are recruitment feasibility and treatment acceptability, defined as a recruitment rate of ≥20% for eligible patients consenting to randomisation and ≥70% completion-rate of patients participating in the treatment condition. A preliminary estimation of the treatment effect based on the mean difference in Patient Health Questionnaire-9 (PHQ-9) scores between intervention and control group six months poststroke is calculated. Secondary endpoints include changes in depression (PHQ-9/ Hamilton Depression Scale) and anxiety (Generalised Anxiety Disorder 7) of all participants across all follow-ups during the first year poststroke.eng
dcterms.accessRightsopen access
dcterms.creatorVolz, Matthias
dcterms.creatorMundiyanapurath, Sibu
dcterms.creatorSchauenburg, Henning
dcterms.creatorMeuth, Sven Guenther
dcterms.creatorWild, Beate
dcterms.creatorWerheid, Katja
dcterms.creatorBarber, Jacques P.
dcterms.creatorSchäfer, Ralf
dcterms.creatorBeerbaum, Luisa
dcterms.creatorDinger, Ulrike
dcterms.source.articlenumber077656
dcterms.source.identifiereissn:2044-6055
dcterms.source.issueIssue 8
dcterms.source.journalBMJ Openeng
dcterms.source.volumeVolume 13
kup.iskupfalse

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