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Induction of protein aggregation and starvation response by tRNA modification defects

dc.date.accessioned2020-11-24T12:54:52Z
dc.date.available2020-11-24T12:54:52Z
dc.date.issued2020-08-29
dc.identifierdoi:10.17170/kobra-202011042071
dc.identifier.urihttp://hdl.handle.net/123456789/12022
dc.description.sponsorshipGefördert im Rahmen des Projekts DEALger
dc.language.isoengeng
dc.rightsNamensnennung 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjecttRNA modificationeng
dc.subjectprotein aggregationeng
dc.subjectdecodingeng
dc.subjectstarvation responseeng
dc.subject.ddc570
dc.titleInduction of protein aggregation and starvation response by tRNA modification defectseng
dc.typeAufsatz
dcterms.abstractPosttranscriptional modifications of anticodon loops contribute to the decoding efficiency of tRNAs by supporting codon recognition and loop stability. Consistently, strong synthetic growth defects are observed in yeast strains simultaneously lacking distinct anticodon loop modifications. These phenotypes are accompanied by translational inefficiency of certain mRNAs and disturbed protein homeostasis resulting in accumulation of protein aggregates. Different combinations of anticodon loop modification defects were shown to affect distinct tRNAs but provoke common transcriptional changes that are reminiscent of the cellular response to nutrient starvation. Multiple mechanisms may be involved in mediating inadequate starvation response upon loss of critical tRNA modifications. Recent evidence suggests protein aggregate induction to represent one such trigger.eng
dcterms.accessRightsopen access
dcterms.creatorKlassen, Roland
dcterms.creatorBruch, Alexander
dcterms.creatorSchaffrath, Raffael
dc.relation.doidoi:10.1007/s00294-020-01103-w
dc.subject.swdTransfer-RNSger
dc.subject.swdModifikation <Biologie>ger
dc.subject.swdAggregationger
dc.subject.swdProteineger
dc.subject.swdDecodierungger
dc.type.versionpublishedVersion
dcterms.source.identifierEISSN 1432-0983
dcterms.source.issueIssue 6
dcterms.source.journalCurrent Geneticseng
dcterms.source.pageinfo1053-1057
dcterms.source.volumeVolume 66
kup.iskupfalse


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