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Synthesis of Geminal Bis- and Tetrakisphosphonate Ester Derivatives and Their Coordination Behavior Towards Ca(II) Ions

dc.date.accessioned2022-09-01T09:46:08Z
dc.date.available2022-09-01T09:46:08Z
dc.date.issued2022-04-05
dc.identifierdoi:10.17170/kobra-202206246402
dc.identifier.urihttp://hdl.handle.net/123456789/14122
dc.description.sponsorshipGefördert im Rahmen des Projekts DEALger
dc.language.isoengeng
dc.rightsNamensnennung 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectbisphosphonateseng
dc.subjectcalciumeng
dc.subjectcoordination chemistry: O ligandseng
dc.subjectphosphoruseng
dc.subjectstructure elucidationeng
dc.subject.ddc540
dc.titleSynthesis of Geminal Bis- and Tetrakisphosphonate Ester Derivatives and Their Coordination Behavior Towards Ca(II) Ionseng
dc.typeAufsatz
dcterms.abstractGeminal Bisphosphonate (BP) Esters in Ca(II) Ion Coordination. A series of geminal BPs was prepared starting from their corresponding ethyl- or isopropyl (arylmethylene)phosphonate ester precursors. Complexation with CaCl₂ yields the derived coordination compounds [Ca(H₂O)₂(L1–L3)₂]Cl₂ or [Ca(L8)Cl₂]ₙ. Their structures in the solid- (SCXRD) as well as solution-state (¹H DOSY NMR) are evaluated and comprehensively compared to literature data. The preparation and thorough characterization of a variety of (arylmethylene)phosphonate ester derivatives (S1–S7) as well as derived geminal bisphosphonate (BP) ester ligands (L1–L7) is presented. Subsequent complexation reactions of CaCl₂ with selected BPs (L1–L3) and a known aliphatic tetrakisphosphonate ester (L8) yield the respective Ca(II) coordination compounds [Ca(H₂O)₂(L1--L3)₂]Cl₂ (C1--C3) and [Ca(L8)Cl₂]ₙ (C4) for potential future application as multi-delivery systems in osteoporosis treatment. Obtained SCXRD and ¹H DOSY-NMR data provide a detailed insight into their solid- as well as solution-state structures extending the so far scarcely found X-ray studies on geminal BP-supported Ca(II) complexes.eng
dcterms.accessRightsopen access
dcterms.creatorKöhne, Ingo
dcterms.creatorPietschnig, Rudolf
dc.relation.doidoi:10.1002/ejic.202200194
dc.subject.swdDiphosphonateger
dc.subject.swdCalciumger
dc.subject.swdKoordinationslehreger
dc.subject.swdLigandger
dc.subject.swdPhosphorger
dc.subject.swdStrukturaufklärungger
dc.type.versionpublishedVersion
dcterms.source.identifiereissn:1099-0682
dcterms.source.issueIssue 17
dcterms.source.journalEurJIC (European Journal of Inorganic Chemistry)eng
dcterms.source.volumeVolume 2022
kup.iskupfalse
dcterms.source.articlenumbere202200194


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Except where otherwise noted, this item's license is described as Namensnennung 4.0 International