Date
2024-04Metadata
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Chitosan hydrogels enriched with bioactive phloroglucinol for controlled drug diffusion and potential wound healing
Abstract
We report a facile strategy to prepare chitosan (CS) hydrogels that eliminates the need for chemical crosslinking for advanced biomedical therapies. This approach gives controlled properties to the hydrogels by incorporating a natural bioactive phenolic compound, phloroglucinol (PG), into their microstructure. The adsorption of PG onto CS chains enhanced the hydrogels' antioxidant activity by up to 25 % and resulted in a denser, more entangled structure, reducing the pore size by 59 μm while maintaining porosity above 94 %. This allowed us to finely adjust pore size and swelling capacity. These structural properties make these hydrogels well-suited for wound healing dressings, promoting fibroblast proliferation and exhibiting excellent hemocompatibility. Furthermore, to ensure the versatility of these hydrogels, herein, we demonstrate their potential as drug delivery systems, particularly for dermal infections. The drug release can be controlled by a combination of drug diffusion through the swollen hydrogel and relaxation of the CS chains. In summary, our hydrogels leverage the synergistic effects of CS's antibacterial and antifungal properties with PG's antimicrobial and anti-inflammatory attributes, positioning them as promising candidates for biomedical and pharmaceutical applications, more specifically in advanced wound healing therapies with local drug delivery.
Citation
In: International Journal of Biological Macromolecules Volume 265 / Part 1 (2024-04) eissn:1879-0003Sponsorship
Gefördert im Rahmen des Projekts DEALCitation
@article{doi:10.17170/kobra-2024052910235,
author={Teixeira Polez, Roberta and Ajiboye, Margaret Adeola and Österberg, Monika and Horn, Marilia Marta},
title={Chitosan hydrogels enriched with bioactive phloroglucinol for controlled drug diffusion and potential wound healing},
journal={International Journal of Biological Macromolecules},
year={2024}
}
0500 Oax 0501 Text $btxt$2rdacontent 0502 Computermedien $bc$2rdacarrier 1100 2024$n2024 1500 1/eng 2050 ##0##http://hdl.handle.net/123456789/15792 3000 Teixeira Polez, Roberta 3010 Ajiboye, Margaret Adeola 3010 Österberg, Monika 3010 Horn, Marilia Marta 4000 Chitosan hydrogels enriched with bioactive phloroglucinol for controlled drug diffusion and potential wound healing / Teixeira Polez, Roberta 4030 4060 Online-Ressource 4085 ##0##=u http://nbn-resolving.de/http://hdl.handle.net/123456789/15792=x R 4204 \$dAufsatz 4170 5550 {{Chitosan}} 5550 {{Acylphloroglucinole}} 5550 {{Hydrogel}} 5550 {{Wundheilung}} 5550 {{Blutstillungsmittel}} 7136 ##0##http://hdl.handle.net/123456789/15792
2024-05-29T09:36:29Z 2024-05-29T09:36:29Z 2024-04 doi:10.17170/kobra-2024052910235 http://hdl.handle.net/123456789/15792 Gefördert im Rahmen des Projekts DEAL eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Chitosan Phloroglucinol Hydrogel Wound healing Drug delivery Hemostatic 540 Chitosan hydrogels enriched with bioactive phloroglucinol for controlled drug diffusion and potential wound healing Aufsatz We report a facile strategy to prepare chitosan (CS) hydrogels that eliminates the need for chemical crosslinking for advanced biomedical therapies. This approach gives controlled properties to the hydrogels by incorporating a natural bioactive phenolic compound, phloroglucinol (PG), into their microstructure. The adsorption of PG onto CS chains enhanced the hydrogels' antioxidant activity by up to 25 % and resulted in a denser, more entangled structure, reducing the pore size by 59 μm while maintaining porosity above 94 %. This allowed us to finely adjust pore size and swelling capacity. These structural properties make these hydrogels well-suited for wound healing dressings, promoting fibroblast proliferation and exhibiting excellent hemocompatibility. Furthermore, to ensure the versatility of these hydrogels, herein, we demonstrate their potential as drug delivery systems, particularly for dermal infections. The drug release can be controlled by a combination of drug diffusion through the swollen hydrogel and relaxation of the CS chains. In summary, our hydrogels leverage the synergistic effects of CS's antibacterial and antifungal properties with PG's antimicrobial and anti-inflammatory attributes, positioning them as promising candidates for biomedical and pharmaceutical applications, more specifically in advanced wound healing therapies with local drug delivery. open access Teixeira Polez, Roberta Ajiboye, Margaret Adeola Österberg, Monika Horn, Marilia Marta 13 Seiten doi:10.1016/j.ijbiomac.2024.130808 Chitosan Acylphloroglucinole Hydrogel Wundheilung Blutstillungsmittel publishedVersion eissn:1879-0003 Part 1 International Journal of Biological Macromolecules Volume 265 false 130808
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