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dc.date.accessioned2020-05-20T06:26:10Z
dc.date.available2020-05-20T06:26:10Z
dc.date.issued2019-12-20
dc.identifierdoi:10.17170/kobra-202005081235
dc.identifier.urihttp://hdl.handle.net/123456789/11563
dc.description.sponsorshipGefördert im Rahmen des Projekts DEAL
dc.language.isoeng
dc.rightsNamensnennung 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject5-HTeng
dc.subjectacetylcholinesterase histochemistryeng
dc.subjectcircadian entrainment pathwayseng
dc.subjectGABAeng
dc.subjectneuropeptideseng
dc.subjectoptic lobe neuropilseng
dc.subjectPDFeng
dc.subjectRRID:AB_177540eng
dc.subjectRRID:AB_2313973eng
dc.subjectRRID:AB_2314414eng
dc.subjectRRID:AB_2314803eng
dc.subjectRRID:AB_2315017eng
dc.subjectRRID:AB_2532101eng
dc.subjectRRID:AB_261181eng
dc.subjectRRID:AB_477522eng
dc.subjectRRID:AB_477652eng
dc.subjectRRID:AB_528479eng
dc.subjectRRID:AB_760350eng
dc.subject.ddc570
dc.titleCandidates for photic entrainment pathways to the circadian clock via optic lobe neuropils in the Madeira cockroacheng
dc.typeAufsatz
dcterms.abstractThe compound eye of cockroaches is obligatory for entrainment of the Madeira cockroach's circadian clock, but the cellular nature of its entrainment pathways is enigmatic. Employing multiple‐label immunocytochemistry, histochemistry, and backfills, we searched for photic entrainment pathways to the accessory medulla (AME), the circadian clock of the Madeira cockroach. We wanted to know whether photoreceptor terminals could directly contact pigment‐dispersing factor‐immunoreactive (PDF‐ir) circadian pacemaker neurons with somata in the lamina (PDFLAs) or somata next to the AME (PDFMEs). Short green‐sensitive photoreceptor neurons of the compound eye terminated in lamina layers LA1 and LA2, adjacent to PDFLAs and PDFMEs that branched in LA3. Long UV‐sensitive compound eye photoreceptor neurons terminated in medulla layer ME2 without direct contact to ipsilateral PDFMEs that arborized in ME4. Multiple neuropeptide‐ir interneurons branched in ME4, connecting the AME to ME2. Before, extraocular photoreceptors of the lamina organ were suggested to send terminals to accessory laminae. There, they overlapped with PDFLAs that mostly colocalized PDF, FMRFamide, and 5‐HT immunoreactivities, and with terminals of ipsi‐ and contralateral PDFMEs. We hypothesize that during the day cholinergic activation of the largest PDFME via lamina organ photoreceptors maintains PDF release orchestrating phases of sleep–wake cycles. As ipsilateral PDFMEs express excitatory and contralateral PDFMEs inhibitory PDF autoreceptors, diurnal PDF release keeps both PDF‐dependent clock circuits in antiphase. Future experiments will test whether ipsilateral PDFMEs are sleep‐promoting morning cells, while contralateral PDFMEs are activity‐promoting evening cells, maintaining stable antiphase via the largest PDFME entrained by extraocular photoreceptors of the lamina organ.eng
dcterms.accessRightsopen access
dcterms.creatorArnold, Thordis
dcterms.creatorKorek, Sebastian
dcterms.creatorMassah, Azar
dcterms.creatorEschstruth, David
dcterms.creatorStengl, Monika
dc.relation.projectidDeutsche Forschungsgemeinschaft. Grant Numbers: STE 531/18‐3, STE 531/21‐1, STE 531/25‐1, STE 531/26‐1
dc.subject.swdKüchenschabeger
dc.subject.swdTagesrhythmusger
dc.subject.swdNervensystemger
dc.type.versionpublishedVersion
dcterms.source.identifierEISSN 1096-9861
dcterms.source.issueIssue 10
dcterms.source.journalJCN The journal of comparative neurologyeng
dcterms.source.pageinfo1754-1774
dcterms.source.volumeVolume 528
kup.iskupfalse


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