Datum
2022-12-03Autor
Huhnstock, RicoReginka, MeikeSonntag, ClaudiusMerkel, MaximilianDingel, KristinaSick, BernhardVogel, MichaelEhresmann, ArnoSchlagwort
530 Physik 600 Technik BiosensorKolloidAngewandte PhysikMagnetwerkstoffMagnetische EigenschaftMetadata
Zur Langanzeige
Aufsatz
Three‑dimensional close‑to‑substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes
Zusammenfassung
The transport of magnetic particles (MPs) by dynamic magnetic field landscapes (MFLs) using magnetically patterned substrates is promising for the development of Lab‑on‑a‑chip (LOC) systems. The inherent close‑to‑substrate MP motion is sensitive to changing particle–substrate interactions. Thus, the detection of a modified particle–substrate separation distance caused by surface binding of an analyte is expected to be a promising probe in analytics and diagnostics. Here, we present an essential prerequisite for such an application, namely the label‑free quantitative experimental determination of the three‑dimensional trajectories of superparamagnetic particles (SPPs) transported by a dynamically changing MFL. The evaluation of defocused SPP images from optical bright‑field microscopy revealed a “hopping”‑like motion of the magnetic particles, previously predicted by theory, additionally allowing a quantification of maximum jump heights. As our findings pave the way towards precise determination of particle–substrate separations, they bear deep implications for future LOC detection schemes using only optical microscopy.
Zitierform
In: Scientific Reports Volume 12 (2022-12-03) eissn:2045-2322Förderhinweis
Gefördert durch den Publikationsfonds der Universität KasselZitieren
@article{doi:10.17170/kobra-202303107612,
author={Huhnstock, Rico and Reginka, Meike and Sonntag, Claudius and Merkel, Maximilian and Dingel, Kristina and Sick, Bernhard and Vogel, Michael and Ehresmann, Arno},
title={Three‑dimensional close‑to‑substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes},
journal={Scientific Reports},
year={2022}
}
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2023-03-17T07:23:14Z 2023-03-17T07:23:14Z 2022-12-03 doi:10.17170/kobra-202303107612 http://hdl.handle.net/123456789/14500 Gefördert durch den Publikationsfonds der Universität Kassel eng Namensnennung 4.0 International http://creativecommons.org/licenses/by/4.0/ Applied physics Biosensors Colloids Magnetic properties and materials 530 600 Three‑dimensional close‑to‑substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes Aufsatz The transport of magnetic particles (MPs) by dynamic magnetic field landscapes (MFLs) using magnetically patterned substrates is promising for the development of Lab‑on‑a‑chip (LOC) systems. The inherent close‑to‑substrate MP motion is sensitive to changing particle–substrate interactions. Thus, the detection of a modified particle–substrate separation distance caused by surface binding of an analyte is expected to be a promising probe in analytics and diagnostics. Here, we present an essential prerequisite for such an application, namely the label‑free quantitative experimental determination of the three‑dimensional trajectories of superparamagnetic particles (SPPs) transported by a dynamically changing MFL. The evaluation of defocused SPP images from optical bright‑field microscopy revealed a “hopping”‑like motion of the magnetic particles, previously predicted by theory, additionally allowing a quantification of maximum jump heights. As our findings pave the way towards precise determination of particle–substrate separations, they bear deep implications for future LOC detection schemes using only optical microscopy. open access Huhnstock, Rico Reginka, Meike Sonntag, Claudius Merkel, Maximilian Dingel, Kristina Sick, Bernhard Vogel, Michael Ehresmann, Arno doi:10.1038/s41598-022-25391-z Biosensor Kolloid Angewandte Physik Magnetwerkstoff Magnetische Eigenschaft publishedVersion eissn:2045-2322 Scientific Reports Volume 12 false Article number: 20890 (2022)
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