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Aufsatz Role of Pseudouridine Formation by Deg1 for Functionality of Two Glutamine Isoacceptor tRNAs 

Klassen, Roland; Schaffrath, Raffael (2017-01-26)
Loss of Deg1/Pus3 and concomitant elimination of pseudouridine in tRNA at positions 38 and 39 (ψ38/39) was shown to specifically impair the function of tRNAGlnUUG under conditions of temperature-induced down-regulation of wobble uridine thiolation in budding yeast and is linked to intellectual disability in humans. To further characterize the differential importance of the frequent ψ38/39 modification for tRNAs in yeast, we analyzed the in vivo function of non-sense suppressor tRNAs SUP4 and sup70-65 in the absence ...
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Aufsatz S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic 

Kailing, Lyn Lisette; Bertinetti, Daniela; Paul, Caroline Emilie; Manszewski, Tomasz; Jaskolski, Mariusz; Herberg, Friedrich W.; Pavlidis, Ioannis V. (2018-03-21)
S-adenosyl-L-homocysteine (SAH) hydrolases (SAHases) are involved in the regulation of methylation reactions in many organisms and are thus crucial for numerous cellular functions. Consequently, their dysregulation is associated with severe health problems. The SAHase-catalyzed reaction is reversible and both directions depend on the redox activity of nicotinamide adenine dinucleotide (NAD+) as a cofactor. Therefore, nicotinamide cofactor biomimetics (NCB) are a promising tool to modulate SAHase activity. In the ...
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Aufsatz Preferential weakening of rotational magnetic anisotropy by keV-He ion bombardment in polycrystalline exchange bias layer systems 

Müglich, Nicolas David; Merkel, Maximilian; Gaul, Alexander; Meyl, Markus; Götz, Gerhard; Reiss, Günter; Kuschel, Timo; Ehresmann, Arno (2018-05-04)
The consequences of keV light-ion bombardment of polycrystalline exchange bias layer systems on individual magnetic anisotropies composing the effective unidirectional magnetic anisotropy are investigated by vectorial magneto-optic Kerr effect measurements. Preferential reduction of rotatable magnetic anisotropy as compared to the other magnetic anisotropies is observable, disproving the intuitive assumption of an equable weakening of all magnetic anisotropies due to the bombardment. It is concluded that light-ion ...
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Aufsatz Chemical tools selectively target components of the PKA system 

Bertinetti, Daniela; Schweinsberg, Sonja; Hanke, Susanne E.; Schwede, Frank; Bertinetti, Oliver; Drewianka, Stephan; Genieser, Hans-Gottfried; Herberg, Friedrich W. (2009-02-12)
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Aufsatz Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog 

Moll, Daniela [früherer Name]; Bertinetti, Daniela; Prinz, Anke; Brendel, Cornelia M.; Berrera, Marco; Guske, Katrin; Zaccolo, Manuela; Genieser, Hans-Gottfried; Herberg, Friedrich W. (2008-06-25)
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Aufsatz Apomorphine alters prey-catching patterns in the common toad: behavioral experiments and 14C-2-Deoxyglucose brain mapping studies 

Glagow, M.; Ewert, J.-P. (1999)
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Aufsatz Responses of single neurons in the toad’s caudal ventral striatum to moving visual stimuli and test of their efferent projection by extracellular antidromic stimulation/recording techniques 

Buxbaum-Conradi, H.; Ewert, J.-P. (1999)
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Aufsatz Biomolecular interaction analysis in functional proteomics 

Moll, Daniela [früherer Name]; Bertinetti, Daniela; Prinz, Anke; Gesellchen, Frank; Drewianka, Stephan; Zimmermann, Bastian; Herberg, Friedrich W. (Springer Verlag, 2006)
In der funktionellen Proteomforschung werden bekannte Interaktionen eines zellulären Netzwerkes qualitativ untersucht. Diese Veröffentlichung beschreibt verschiedene biomolekulare Interaktionsanalysen, anhand des Modellsystems PKA, die zur detaillierten Charakterisierung von Bindungen herangezogen werden können. Neben den Gleichgewichtsbindungsdaten (generiert aus AlphaScreen, FP, SPR und ITC Messungen) wurden aus ITC Messungen die thermodynamischen Parameter G, H und S ermittelt. Durch Anwendung der BRET2 ...
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Aufsatz Comparative thermodynamic analysis of cyclic nucleotide binding to protein kinase A 

Moll, Daniela [früherer Name]; Schweinsberg, Sonja; Hammann, Christian; Herberg, Friedrich W.; Bertinetti, Daniela (2007)
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Aufsatz Enzymkinetik in der Schule 

Müller, Sara; Kromke, Marianne; Vogt, Helmut; Moll, Daniela [früherer Name]; Bertinetti, Daniela (Wiley-VCH, 2007-08)
Urease ist ein Enzym, das Harnstoff spaltet und dessen Reaktionsgeschwindigkeit leicht mittels Leitfähigkeitsmessungen bestimmt werden kann. Dieses Experiment kann, als Schüler- oder Demonstrationsversuch, im Biologie- und Chemieunterricht der Oberstufe von qualitativen Betrachtungen bis hin zur Ermittlung komplexer kinetischer Beschreibungen (Michaelis-Menten-Kinetik) ausgewertet werden.
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