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Dissertation
The anatomy of velvet worms (Onychophora) as revealed by a multimethodological approach and three-dimensional reconstructions
(2024)
Onychophorans, or velvet worms, comprise a small group of worm-like, multi-legged terrestrial invertebrates. Since their discovery in 1826, these organisms have been investigated from different perspectives, particularly in the field of morphology—a discipline that provides the basis for functional and evolutionary inferences. Onychophorans are currently classified within Ecdysozoa (moulting animals) and form together with Tardigrada (water bears) and Arthropoda a clade named Panarthropoda. Therefore, onychophorans ...
Dissertation
Biochemical Characterization of Microtubule-Associated Serine/Threonine Kinases
(2023)
The association of human microtubule-associated serine/threonine (MAST) kinases with different diseases, such as neurodevelopmental disorders and cancer, leads to hight interest in understanding the function of these understudied kinases. This PhD thesis provides the first consolidated biochemical analysis of three different human MAST kinases (MAST1-3) and the Drosophila melanogaster homologue drop out protein (DOP).
Dissertation
Functional Analysis of Src42A in embryonic epithelial morphogenesis of Drosophila melanogaster
(2023)
Src42A is one of the Src family kinases (SFKs) present in Drosophila melanogaster. In mammals there are 8 SFKs and so far, a loss of function analysis of SFKs were difficult to conduct due to their functional redundancy. In Drosophila, there are only two SFKs namely Src42A and Src64B, the former is essential for embryonic development and the latter is a non-essential gene. Since Src42A is supplied as a maternal component, the zygotic mutant were showing defects in later developmental stages, because the contribution ...
Dissertation
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Ash dieback : the pathogen Hymenoscyphus fraxineus and other fungi associated with stem collar necroses of common ash
(2024)
The ascomycete Hymenoscyphus fraxineus has caused devastating damage to the common ash (Fraxinus excelsior) in Europe in recent decades, resulting in considerable economic and ecological losses. The ash dieback pathogen is native to Asia, where it lives mainly as a saprobiont in peaceful coexistence with the Asian ash species Fraxinus mandshurica. Symptoms of the fungus in common ash include wilting of the leaves with subsequent dieback of shoots, twigs and branches, as well as damage to the stem base. These stem ...
Dissertation
Einfluss verschiedener Lipidstoffwechselwege auf die Entwicklung von Dictyostelium discoideum
(2024)
In den meisten Organismen spielen Lipid Droplets (LDs) eine positive Rolle beim Überleben einiger Stress-Bedingungen wie Nahrungsmangel. Axenisch wachsende D. discoideum haben keine LDs, sie sind „lean cells“, aber nach der Zugabe von 200 μM Palmitinsäure (PA) zum Kulturmedium synthetisieren die Zellen nach 3 h hunderte von LDs und werden zu „fat cells“. Überraschenderweise sterben die fat cells während der Nahrungsmangel-induzierten Entwicklung ab und bilden daher kaum Sporen. Neben dem Hauptneutrallipid Triacylglycerol ...
Dissertation
Regulatory mechanisms of Protein kinase A - Isoform mediated fine-tuning
(2023)
cAMP-dependent protein kinase (PKA) is a crucial part in eukaryotic signal transduction and controls biological processes. With a multitude of substrates, a great variety of cellular functions are regulated by PKA. Regulation of metabolism, cell growth and -differentiation, conductivity of ion channels, movement of sperm cells, embryonic development, neuroplasticity as well as conversion of short- to long-term memory are just examples for the many tasks of the kinase. To achieve and coordinate these diverse functions, ...
Dissertation
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Populationsgenetik und Phylogeographie des Großen Immergrüns (Vinca major L.; Apocynaceae) im autochthonen vs. allochthonen Verbreitungsgebiet
(2023-04-21)
Populationsgenetik und Phylogeographie des Großen Immergrüns (Vinca major L.; Apocynaceae) im autochthonen vs. allochthonen Verbreitungsgebiet
Das Große Immergrün (Vinca major L., Apocynaceae) stammt aus dem Mittelmeerraum und wurde durch den Menschen als Nutz-, Arznei- und Zierpflanze sowie wegen seiner mythologischen Bedeutung in zahlreiche zuvor unbesiedelte Gebiete verschleppt. In einigen Regionen des allochthonen Areals (Australien, Neuseeland, USA) gilt V. major als invasiv und wird massiv bekämpft. Ziel ...