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Now showing items 41-48 of 48
Dissertation
Elimination in Operator Algebras
(2014-08-08)
A large class of special functions are solutions of systems of linear difference and differential equations with polynomial coefficients. For a given function, these equations considered as operator polynomials generate a left ideal in a noncommutative algebra called Ore algebra. This ideal with finitely many conditions characterizes the function uniquely so that Gröbner basis techniques can be applied.
Many problems related to special functions which can be described by such ideals can be solved by performing ...
Dissertation
Identifikation spezieller Funktionen, die durch Rodriguesformeln gegeben sind
(2016-03-03)
Es ist allgemein bekannt, dass sich zwei gegebene Systeme spezieller Funktionen durch Angabe einer Rekursionsgleichung und entsprechend vieler Anfangswerte identifizieren lassen, denn computeralgebraisch betrachtet hat man damit eine Normalform vorliegen. Daher hat sich die interessante Forschungsfrage ergeben, Funktionensysteme zu identifizieren, die über ihre Rodriguesformel gegeben sind.
Zieht man den in den 1990er Jahren gefundenen Zeilberger-Algorithmus für holonome Funktionenfamilien hinzu, kann die Rodriguesformel ...
Preprint
Convergence analysis of time-discretization schemes for rate-independent systems
(2017-12-21)
It is well known that rate-independent systems involving nonconvex energy functionals in general do not allow for time-continuous solutions even if the given data are smooth. In the last years, several solution concepts were proposed that include discontinuities in the notion of solution, among them the class of global energetic solutions and the class of BV-solutions. In general, these solution concepts are not equivalent and numerical schemes are needed that reliably approximate that type of solutions one is ...
Preprint
Characterization theorem for classical orthogonal polynomials on non-uniform lattices: The functional approach
(2010)
Using the functional approach, we state and prove a characterization theorem for classical orthogonal polynomials on non-uniform lattices (quadratic lattices of a discrete or a q-discrete variable) including the Askey-Wilson polynomials. This theorem proves the equivalence between seven characterization properties, namely the Pearson equation for the linear functional, the second-order divided-difference equation, the orthogonality of the derivatives, the Rodrigues formula, two types of structure relations,and the ...
Preprint
On Solution Sets of Information Inequalities
(2011)
We investigate solution sets of a special kind of linear inequality systems. In particular, we derive characterizations of these sets in terms of minimal solution sets. The studied inequalities emerge as information inequalities in the context of Bayesian networks. This allows to deduce important properties of Bayesian networks, which is important within causal inference.
Aufsatz
Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction
(2018-06-15)
The pregnane X receptor (PXR) is a drug/xenobiotic-activated transcription factor of crucial importance for major cytochrome P450 xenobiotic-metabolizing enzymes (CYP) expression and regulation in the liver and the intestine. One of the major target genes regulated by PXR is the cytochrome P450 enzyme (CYP3A4), which is the most important human drug-metabolizing enzyme. In addition, PXR is supposed to be involved both in basal and/or inducible expression of many other CYPs, such as CYP2B6, CYP2C8, 2C9 and 2C19, CYP3A5, ...
Aufsatz
Three-Dimensional Gradients of Cytokine Signaling between T Cells
(2015-04-29)
Immune responses are regulated by diffusible mediators, the cytokines, which act at sub-nanomolar concentrations. The spatial range of cytokine communication is a crucial, yet poorly understood, functional property. Both containment of cytokine action in narrow junctions between immune cells (immunological synapses) and global signaling throughout entire lymph nodes have been proposed, but the conditions under which they might occur are not clear. Here we analyze spatially three-dimensional reaction-diffusion models ...
Aufsatz
PDE/ODE modeling and simulation to determine the role of diffusion in long-term and -range cellular signaling
(2015-10-14)
Background
We study the relevance of diffusion for the dynamics of signaling pathways. Mathematical modeling of cellular diffusion leads to a coupled system of differential equations with Robin boundary conditions which requires a substantial knowledge in mathematical theory. Using our new developed analytical and numerical techniques together with modern experiments, we analyze and quantify various types of diffusive effects in intra- and inter-cellular signaling. The complexity of these models necessitates suitable ...