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Aufsatz
tRNA anticodon loop modifications ensure protein homeostasis and cell morphogenesis in yeast
(2016-08-05)
Using budding yeast, we investigated a negative interaction network among genes for tRNA modifications previously implicated in anticodon-codon interaction: 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm5s2U34: ELP3, URM1), pseudouridine (Ψ38/39: DEG1) and cyclic N6-threonyl-carbamoyl-adenosine (ct6A37: TCD1). In line with functional cross talk between these modifications, we find that combined removal of either ct6A37 or Ψ38/39 and mcm5U34 or s2U34 results in morphologically altered cells with synthetic growth defects. ...
Aufsatz
Meta-Heuristics in Short Scale Construction: Ant Colony Optimization and Genetic Algorithm
(2016-11-28)
The advent of large-scale assessment, but also the more frequent use of longitudinal and multivariate approaches to measurement in psychological, educational, and sociological research, caused an increased demand for psychometrically sound short scales. Shortening scales economizes on valuable administration time, but might result in inadequate measures because reducing an item set could: a) change the internal structure of the measure, b) result in poorer reliability and measurement precision, c) deliver measures ...
Aufsatz
Lower-extremity resistance training on unstable surfaces improves proxies of muscle strength, power and balance in healthy older adults: a randomised control trial
(2016-11-24)
Background:
It is well documented that both balance and resistance training have the potential to mitigate intrinsic fall risk factors in older adults. However, knowledge about the effects of simultaneously executed balance and resistance training (i.e., resistance training conducted on unstable surfaces [URT]) on lower-extremity muscle strength, power and balance in older adults is insufficient. The objective of the present study was to compare the effects of machine-based stable resistance training (M-SRT) and ...
Aufsatz
Die Rolle der Regionalplanung im Umgang mit Windenergiekonflikten in Deutschland und Perspektiven für die raumbezogene Forschung
(2016-10-14)
In Deutschland hat die Regionalplanung eine Schlüsselrolle bei der Ausweisung von Gebieten für die Windenergienutzung.Mit Instrumenten wie Vorrang-, Eignungs- und Ausschlussgebieten kann sie Flächen verbindlich festlegen, die für die Nutzung der Windenergie geeignet sind. Dadurch ist sie zwischen die Fronten der Windkraftbefürworter und -gegner geraten. Die einen sehen Windenergie als effiziente, saubere und sichere Energiequelle sowie Alternative zu nichtregenerativen Energieträgern. Für die anderen sind Windenergieanlagen ...
Aufsatz
No Evidence for Ionotropic Pheromone Transduction in the Hawkmoth Manduca sexta
(2016-11-09)
Insect odorant receptors (ORs) are 7-transmembrane receptors with inverse membrane topology. They associate with the conserved ion channel Orco. As chaperon, Orco maintains ORs in cilia and, as pacemaker channel, Orco controls spontaneous activity in olfactory receptor neurons. Odorant binding to ORs opens OR-Orco receptor ion channel complexes in heterologous expression systems. It is unknown, whether this also occurs in vivo. As an alternative to this ionotropic transduction, experimental evidence is accumulating ...
Aufsatz
Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast
(2016-10-24)
Urm1 is a unique dual-function member of the ubiquitin protein family and conserved from yeast to man. It acts both as a protein modifier in ubiquitin-like urmylation and as a sulfur donor for tRNA thiolation, which in concert with the Elongator pathway forms 5-methoxy-carbonyl-methyl-2-thio (mcm5s2) modified wobble uridines (U34) in anticodons. Using Saccharomyces cerevisiae as a model to study a relationship between these two functions, we examined whether cultivation temperature and sulfur supply previously ...
Aufsatz
High-Quality Solid Fuel Production from Leaf Litter of Urban Street Trees
(2016-11-30)
Leaf litter is a growing concern for cities. Due to adherent dirt such biomass is rarely utilized nowadays but may constitute a renewable energy source for communities or private households. Leaf litter from main roads, residential areas and city centres collected by the vacuum technique or the sweeper technique was sampled and analysed for ash content and chemical composition. Ash content of leaf litter collected by the sweeping technique was higher (21.6%–40.1% dry matter, DM) than in material collected by the ...
Aufsatz
Linking entrepreneurial orientation to firm performance in a post-socialist market context: the case of Hungary
(2016)
Entrepreneurial orientation provoked the interest of numerous scholars as well as political and administrative decision-makers. Both start-ups and already established corporate entities are increasingly persecuting new opportunities, products, and business models in order to establish superiority above their competitive environment. The tendencies evince an optimist impact of entrepreneurial orientation on business performance, namely on financial performance. Beyond the aforementioned relationship, there are impulses ...
Aufsatz
Total Site Utility Systems Optimisation for Milk Powder Production
(2016)
This study applies the Total Site Heat Integration method, in conjunction with a detailed process and utility model, to investigate three methods to increase the energy efficiency of the utility supply system for milk powder production. Sequentially explored opportunities are: (1) increasing boiler efficiency through condensing economisers, (2) waste heat recovery from the chiller unit, and (3) Combined Heat and Power (CHP) for electricity production. The basis for the analysis is the anticipated future milk powder ...
Aufsatz
Introducing the Logarithmic finite element method: a geometrically exact planar Bernoulli beam element
(2016-09-15)
We propose a novel finite element formulation that significantly reduces the number of degrees of freedom necessary to obtain reasonably accurate approximations of the low-frequency component of the deformation in boundary-value problems. In contrast to the standard Ritz–Galerkin approach, the shape functions are defined on a Lie algebra—the logarithmic space—of the deformation function. We construct a deformation function based on an interpolation of transformations at the nodes of the finite element. In the case ...