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Now showing items 41-50 of 62
Dissertation
Pathogenic Mutations in Catalytic Subunit Isoforms of the cAMP-Dependent Protein Kinase
(2023)
Protein kinase A (PKA) is an integral part in a myriad of cellular pathways and a main effector of the second messenger cAMP. Since its discovery in the late 1960s, PKA has become one of the best-studied eukaryotic protein kinases in terms of enzymatic and structural features. Pathological implications of PKA have just started to emerge. There are three main isoforms (α, β, γ) of the catalytic subunit of PKA (PKA-C) which constitute a holoenzyme (R2C2) by association with a regulatory subunit (PKA-R) dimer. While ...
Dissertation
Orometry, Intrinsic Dimensionality and Learning: Novel Insights into Network Data
(2023-11)
Today, networks are an integral part of our world. Let it be real-life friendship networks or social connections that are based on social media. In this thesis, we contribute to the understanding of networks by studying networks from three different perspectives. First, we adapt notions and concepts from orometry to metric data and networks to gain novel insights from a local perspective. Specifically, we study measures of local outstandingness and propose concepts to derive small hierarchies from larger networks. ...
Dissertation
Management effects on soil microbial functions at a South-Indian rural-urban interface
(2023-06)
Urbanization leads to effects on many aspects of ecosystems and societies. Among the affected are agricultural systems and, specifically, soils. One of the most evident pathways of urbanization effects on agricultural soils is through an increased demand for agricultural commodities requiring agricultural intensification, hence, changes in management practices that alter soils.
In this context, the purpose of this study was to understand how the main agricultural management practices taking place in urbanizing ...
Dissertation
Asymmetric magnetization reversal processes in exchange-biased microstructures
(2023)
Over the last decades, the exchange bias (EB) effect has captured the attention of the research community striving for high-density logic memory devices and sensitive sensor technologies based on bi-, multilayered, or patterned magnetic thin film systems. Macroscopically, the EB manifests in a horizontal shift of the ferromagnetic remagnetization loop and an enhancement of the coercivity, both connected to the induced unidirectional anisotropy (UDA) at the exchange-coupled ferromagnetic/antiferromagnetic interface. ...
Dissertation
Generation Human Body Motion by the Centralized Networks
(2023)
The main goal of the thesis is to describe and study reduced models for efficient simulations of human body motions (HBM). To this end, we propose new coupled oscillator models, which are networks of dynamically coupled elements. These networks consist of a few of centers and many satellites. The centers evolve in time as periodical oscillators with different frequencies. The satellite states are defined via center states by a radial basis function (RBF) networks. To simulate different motions we adjust the parameter ...
Dissertation
Regionalisierung von E-Kfz-Ladestellen in Szenarien für den zukünftigen Ausbau in Deutschland
(2023-04)
Ein wesentlicher Baustein zur Senkung der CO2-Emissionen im Verkehrssektor ist die Elektrifizierung des Individualverkehrs, wobei die schnell wachsende Lade-infrastruktur Auswirkungen auf das Stromnetz hat. Netzberechnungen erfordern die räumliche Verortung von zukünftigen Ladestellen. Die vorliegende Arbeit mo-delliert dafür Heimladestellen und öffentlich zugängliche Ladestellen holistisch und punktgenau, und ist für alle Gemeinden in Deutschland anwendbar. Zunächst wird die Anzahl an Elektrofahrzeugen und Ladestellen ...
Dissertation
Economic Aspects of Market-based Flexibility for Electricity Networks
(2023)
This thesis contributes to the discussion of the utilization of network-supportive flexibility, in particular in the context of local flexibility markets (LFM). The thesis comprises five articles that are methodologically related but can be read independently. The focus of the investigations is on economic aspects and short- and medium-term market processes.
Chapter 1 provides an introduction to the topic including the definition of the most important terms. Chapter 2 includes the paper, “Design of regional flexibility ...
Dissertation
Ultraschnelle kohärente Kontrollmethoden für die nichtlineare Mikroskopie und Spektroskopie
(2023-11-28)
Ultrakurze Laserpulse im Nanojoule-Energiebereich auf der Femto- bis Pikosekunden-Zeitskala ermöglichen die Erzeugung immenser Feldstärken bei Fokussierung auf wenige Quadratmikrometer Fläche. In diesem Szenario wirken starke Kräfte auf die Elektronensysteme von Atomen und Molekülen im Fokus ein, so dass sich die linearen optischen Eigenschaften von Stoffen ändern können – nichtlineare Eigenschaften treten zutage. Mit einem Pulsformer kann auf die breiten Spektren ultrakurzer Laserpulse per spektraler Phasenmodulation ...
Dissertation
On the analysis of path-dependent functionals of stochastic PDEs
(2023)
Weak approximation methods for stochastic partial differential equations (SPDEs) are concerned with approximating the probability distribution of the solution process rather than the realizations of the solution process itself. In this thesis, we provide new results and methods concerning the weak error analysis of numerical approximations of path-dependent functionals of solution processes of SPDEs. Two separate approaches to analyzing weak approximation errors are considered: the Itô calculus approach and the ...
Dissertation
Structural Design Pedagogy for Architects: Fostering Cross-Disciplinary Integration and Innovation
(2023)
This study develops and presents a qualitative and design-oriented approach to structural
design education as part of architectural education. Existing approaches to structural
design in architectural education for the most part seek to emulate, adapt and
simplify contents and methods typically employed within civil engineering education,
where structures are primarily understood and taught within the framework of static
principles and numerical analysis. In architectural practice, observations however show
that ...