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Dissertation
Development of digital fluorescence light sheet microscopy for high-resolution optical imaging
(2021-12-15)
In modern biology investigating the morphological development of an organism is an inevitable task. Optical microscopy has been extensively used to monitor the live tissue changes in a model organism and it is typically used in conjunction with white light or fluorescence microscopy. The fluorescence microscopy occupies a significant place in biological research due to its ability to address various biological question at subcellular level of a biological sample. One of the more recent developments in fluorescence ...
Habilitation
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Numerical Methods for Fluid Flow: High Order SBP Schemes, IMEX Advection-Diffusion Splitting and Positivity Preservation for Production-Destruction PDEs
(2021-01)
The current demands regarding the numerical simulation of fluid flow often require highly accurate computations to obtain a detailed resolution of the occurring physical phenomena. The basic concept for the construction of a fluid solver is to transfer the physical model into a numerical scheme which complies with the underlying physical principles such as conservation and balances of certain quantities. In addition, the numerical methods are required to be stable and efficient. Again, stability is often determined ...
Dissertation
Synthese von [3]Ferrocenophanen und Ferrocen-verbrückten Oligophosphanen zur (elektro-)chemischen Erzeugung Phosphor-basierter Radikale
(2021-12)
Phosphor-basierte Radikale wurden in der Vergangenheit neben der bewährten Verwendung zur Phosphanierung von (an-)organischen Verbindungen auch als Reduktionsmittel in Einzelelektronen-Transfer-Reaktionen, als Radikalstarter oder als Flammschutzmittel eingesetzt. Ein geeigneter Weg, solche Radikale zu erzeugen, führt über eine thermisch induzierte homolytische Spaltung einer zentralen, sterisch abgeschirmten, elektronenreichen Bindung wie in Bisaminodiphosphanen X₂P PX₂ (X = NR₂). Ein Nachteil sind hier die meist ...
Dissertation
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Investigations on Diamond Thin Films as Implant Coating and Biosensing Platform
(2021)
Diamond is researched in biological context for decades. Fundamental research has established diamond as a material that combines a pronounced compatibility with biological entities and resilience against even the harshest chemical and physical conditions. The present dissertation strives to improve the abilities of diamond in this matter even further by utilizing methods of nanostructuring and biochemical functionalization. Numerous characterization methods are used to monitor each step in detail and to evaluate the ...
Dissertation
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Optimal Control of Quantum Information Tasks in Open Quantum Systems
(2020-07-30)
Every quantum system inevitably interacts with its environment. This is a fundamental requirement that allows us to control, measure and, in general, interact with quantum systems. In that respect, a quantum system's openness can be interpreted as prerequisite that enables quantum technologies in the first place. The latter are built to harness the intrinsic quantum mechanical behavior of quantum devices in order to build new, powerful technologies. However, a quantum system's openness also causes it to interact ...
Lehrmaterial
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Skriptum zur Linearen Algebra und Analytischen Geometrie
(2020-07)
Vorlesungsskript zur Vorlesung „Lineare Algebra und Analytische Geometrie“ an der Universität Kassel im Sommersemester 2020. Es handelt sich um die Druckversion.
Dissertation
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Development of Carrier-Envelope-Phase-Stabilized, mJ-Class Laser Sources Generating Intense, Few-Cycle Laser Pulses
(2020-05-19)
Over a decade ago the frontiers of ultrashort physics and nonlinear optics have reached the attosecond timescale ($1 as = 10 ^ {-18} s$) . Currently, in order to generate isolated attosecond pulses, an intense femtosecond pulse is focused in a jet of a noble gas. Given the sufficient intensity, this leads to high harmonic generation (HHG), which can be filtered (gated) to create a single isolated attosecond pulse. The laser source for the driver pulses has to fulfill two requirements: the pulses need to be limited ...
Dissertation
Morphological and functional examination of neuropeptides in the circadian system of Rhyparobia maderae with special focus on myoinhibitory peptides
(2021)
Die circadiane Uhr terrestrischer Organismen erlaubt die Anpassung von Physiologie und Verhalten an 24 h Rhythmen der Umwelt wie beispielsweise den täglichen Licht-Dunkel-Wechsel. Rhyparobia maderae wurde als Organismus zur Forschung an der inneren Uhr etabliert. Die circadiane Uhr der Madeira Schabe ist die akzessorische Medulla (AME) im optischen Lobus, welche von etwa 240 Neuronen innerviert wird. Diese Neuronen exprimieren und kolokalisieren auffällig viele Neuropeptide, die als Neuromodulatoren/Neurotransmitter ...
Dissertation
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Synthese von Ester- und Etherlipiden durch die GPAT/AGPAT-Proteinfamilie und Lipin in Dictyostelium
(2021-05-12)
The synthesis of glycerolipids starts with the acylation of lipid backbones. Two structurally different glycerolipids emerge in the cell: ether-lipids and ester-lipids. In the case of ether-lipids the first fatty acid is substituted with a fatty alcohol inside the peroxisome. By the characterization of the protein FARAT in this thesis, a key enzyme in etherlipid-synthesis was identified for D. discoideum. FARAT shows a peroxisomal localization and is in principle able to do two jobs. Firstly, it initiates the peroxisomal ...
Dissertation
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Ferrocen-basierte N-heterocyclische Tetrylene mit tertiären Alkylsubstituenten an den Stickstoff-Atomen
(2020)
In 2009, our group published two stable N-heterocyclic carbenes (NHCs) with a 1,1'-ferrocenediyl backbone (fc), which formally exhibit a six-membered FeIIC2N2CII-heterocycle. The stabilization of the fcNHCs is favored by bulky N-substituents. So far neopentyl and 2-adamantyl have been used for this purpose - a bulky primary and secondary alkyl substituent. In contrast to other cyclic diaminocarbenes, the fcNHCs are capable of activating small molecules such as NH3 or CO. The reason for this remarkable ability is the ...