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Dissertation
Finite Element Simulations for the Design of Therapeutic Approaches for Retinal Diseases
(2022)
The retinal disease age-related macular degeneration is the most common cause of vision loss in industrialized countries. In this thesis, motivated by the drug (antibody) treatment of this disease, we designed long-term three dimensional Finite Element simulations of the drug distribution in the healthy human eye. The underlying model consists of a time-dependent convection-diffusion equation coupled to a stationary Darcy equation describing the flow of the aqueous humor through the vitreous medium. We replaced the ...
Dissertation
Generalized Involutive Bases and Their Induced Free Resolutions
(2022-05)
In this thesis, we generalize several types of involutive and marked bases for ideals in quotient rings of commutative polynomial rings. We apply these new types of bases to the analysis of infinite free resolutions and of Hilbert schemes defined over certain types of quotient rings. We are mostly concerned with Pommaret and Janet bases; the marked bases we consider are marked over monomial submodules that are quasi-stable, i.e., that possess finite Pommaret bases.
Involutive bases of the types we consider induce ...
Dissertation
Algorithmic Reduction of Biochemical Reaction Networks
(2022-02-25)
The dynamics of species concentrations of chemical reaction networks are given by autonomous first-order ordinary differential equations. Singular perturbation methods allow the computation of approximate reduced systems that make explicit several time scales with corresponding invariant manifolds. This thesis presents:
1. An algorithmic approach for the computation of such reductions on solid analytical grounds. Required scalings are derived using tropical geometry. The existence of invariant manifolds is subject ...
Technischer Report
Dokumentation der Erhebungsinstrumente des Projekts WiGeMath
(2022-05)
Der Anlass für das Projekt WiGeMath („Wirkungen und Gelingensbedingungen von mathematischen Unterstützungsmaßnahmen in der Studieneingangsphase“ FKZ: 01PB14015A & 01PB14015B) war, dass Wirksamkeit und Gelingensbedingungen von Unterstützungsmaßnahmen in der Studieneingangsphase, die Schwierigkeiten im Übergang von der Schule zur Hochschule lindern sollten, vorher kaum systematisch und zielgerichtet untersucht wurden: Evaluationserhebungen beschränkten sich überwiegend auf lokale und ad hoc gestaltete Zufriedenheitsabfragen ...
Dissertation
Optimal control of a rate-independent system constrained to parameterized balanced viscosity solutions
(2022)
In this dissertation, we analyze an optimal control problem governed by a rate-independent system in an abstract infinite-dimensional setting. The rate-independent system is characterized by a nonconvex stored energy functional, which depends on time via a time-dependent external loading, and by a convex dissipation potential, which is assumed to be bounded and positively homogeneous of degree one.
The optimal control problem uses the external load as control variable and is constrained to normalized ...
Dissertation
Development of a Preconditioning Scheme for Real Gases using Asymptotic Expansions
(2022)
Bei der Beschreibung von Strömungen wird klassischerweise zwischen inkompressiblen und kompressiblen Bereichen unterschieden. Während inkompressible Strömungen durch ein divergenzfreies Geschwindigkeitsfeld charakterisiert werden, sind kompressible Strömungsfelder durch Expansionsfächer, Kontaktunstetigkeiten und Stoßwellen gekennzeichnet. Die beiden Bereiche werden damit durch stark unterschiedliche Systeme partieller Differentialgleichungen beschrieben. Diese Unterscheidung zeigt sich auch in der numerischen ...