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Anonymisierung von Patientendaten durch Fremdlabore für Dritte
(2023-05-25)
Medizinische Diagnostik findet oft in einem Netzwerk statt. Proben oder Gesundheits(roh)daten werden von Ärztinnen und Ärzten erhoben und von diesen an Fremdlabore zur Diagnostik weitergeleitet. Diese Labore bedienen sich dann oft weiterer Dienste, um Verfahren zu beschleunigen oder Ergebnisse zu verbessern (Dritte). Der Beitrag betrachtet die datenschutzrechtlichen Implikationen dieses Vorgehens aus der Perspektive eines Fallbeispiels aus der Blutbildanalyse (I.) und eines entsprechenden Systemsaufbaus zur ...
Aufsatz
Mental health and stress level of Ukrainians seeking psychological help online
(2023-11-04)
Due to the Russian invasion of Ukraine on February 24th, 2022, more than 8 million Ukrainians have been displaced from their homes. Ukrainians exposed to armed conflict and migration are likely to have low levels of mental health status and seek help. We provide a uniform quantitative assessment of the mental health conditions of Ukrainians seeking help soon after the invasion and resettlement. We screen the mental well-being and psychological distress of 1165 refugees, migrants, internally displaced, and non-displaced ...
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The impact of testosterone-lowering medication on recidivism in individuals convicted of sexual offenses
(2024-06-05)
Introduction: Treatment of individuals who have committed sexual offences with Testosterone-Lowering Medication (TLM) is a comparatively intrusive kind of intervention, which regularly takes place in coercive contexts. Thus, the question of efficacy, but also the question of who should be treated, when and for how long, are of great importance. Methods: Recidivism rates of TLM-treated high-risk individuals (þTLM; n¼54) were compared with high-risk individuals treated with psychotherapy only in the same forensic ...
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Integrative-interpersonal dynamic therapy for poststroke depression (INID): study protocol of a randomised controlled pilot trial
(2023-08-08)
Introduction Depression is the most frequent psychiatric disorder following stroke, affecting about one-third of stroke survivors. Patients experience poorer recovery, lower quality of life and higher mortality compared with stroke survivors without depression. Despite these well-known malign consequences, poststroke depression (PSD) is regarded underdiagnosed and undertreated. Evidence of beneficial effects of psychotherapy to treat PSD remains scarce and inconclusive and is limited by heterogeneity in design, content ...
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Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2
(2023-08-08)
In yeast, Elongator-dependent tRNA modifications are regulated by the Kti11•Kti13 dimer and hijacked for cell killing by zymocin, a tRNase ribotoxin. Kti11 (alias Dph3) also controls modification of elongation factor 2 (EF2) with diphthamide, the target for lethal ADP-ribosylation by diphtheria toxin (DT). Diphthamide formation on EF2 involves four biosynthetic steps encoded by the DPH1-DPH7 network and an ill-defined KTI13 function. On further examining the latter gene in yeast, we found that kti13Δ null-mutants ...
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Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2
(2020-04-07)
Proteins of the 14-3-3 family are well known modulators of the leucine-rich repeat kinase 2 (LRRK2) regulating kinase activity, cellular localization, and ubiquitylation. Although binding between those proteins has been investigated, a comparative study of all human 14-3-3 isoforms interacting with LRRK2 is lacking so far. In a comprehensive approach, we quantitatively analyzed the interaction between the seven human 14-3-3 isoforms and LRRK2-derived peptides covering both, reported and putative 14-3-3 binding sites. ...
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Zur soziologischen Auseinandersetzung mit Gewalt in der Medizin am Beispiel des medizinischen Kinderschutzes
(2020-07-03)
Der medizinische Kinderschutz ist ein durch die gegenwärtige deutsche Soziologie kaum beachtetes Phänomen. Der Artikel möchte auf der einen Seite spezifische Entwicklungen des medizinischen Kinderschutzes aufzeigen. Hierzu wird aus einer wissenssoziologischen Perspektive insbesondere auf seine Entstehung, Entwicklung der Definitionen von Misshandlung, die Diagnose verschiedener Formen von Gewalt und auf die Rolle der medizinischen Forschung eingegangen. Auf der anderen Seite sollen besondere Dynamiken und Folgen, ...