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Dissertation
Structural insights into the allosteric activation mechanism of cGMP-dependent protein kinase I
(2016-05-09)
Cyclic GMP-dependent protein kinase (PKG) is a key transducer in the NO-cGMP signaling pathway. In this line, PKG has been considered an important drug target for treating hypertensive cardiovascular and pulmonary diseases. However, the investigation of PKG’s allosteric activation mechanism has been hampered by a lack of structural information. One of the fundamental questions on the cGMP-dependent activation of PKG is how the enzyme can distinguish cGMP over cAMP and selectively respond to cGMP. To ensure proper ...
Teil eines Buches
Das Geschlecht der Opfertiere
(transcript, 2016)
Im biblischen Israel gehört das Opfern von Tieren zu den basalen rituellen Ausdrucksformen, mit denen Menschen in eine Beziehung zum Göttlichen treten. Auch die Erinnerung an das Grunddatum der Geschichte Israels – den Exodus – in der Pessachfeier ist mit der ritualisierten Tötung von Tieren verbunden. Ob das Schlachten des Pessach-Lamms wirklich als Opfer zu qualifizieren ist, bleibt strittig. Unstrittig aber ist, dass die Schlachtung eines »fehlerfreien, männlichen, einjährigen Lamms, des Jungen eines Schafes oder ...
Aufsatz
Evaluation of breeding strategies for polledness in dairy cattle using a newly developed simulation framework for quantitative and Mendelian traits
(2016-06-29)
Background: Intensified selection of polled individuals has recently gained importance in predominantly horned dairy cattle breeds as an alternative to routine dehorning. The status quo of the current polled breeding pool of genetically-closely related artificial insemination sires with lower breeding values for performance traits raises questions regarding the effects of intensified selection based on this founder pool.
Methods: We developed a stochastic simulation framework that combines the stochastic simulation ...
Teil eines Buches
Männlichkeit in Kampf und Schmerz
(Peeters Publishers, 2016)
Die folgenden Ausführungen sind aus zwei Workshops zur Genderperspektive in den Samuelbüchern erwachsen. In dem einen ging es um „Frauen und Männer in Kampf und Krieg", im andern um „Männer und Frauen in Situationen der Trauer".
Konferenzveröffentlichung
Beyond Ritz-Galerkin: Finite element approximations on a manifold in the configuration space [Abstract]
(Institute of Structural Analysis and Antiseismic Research, School of Civil Engineering, National Technical University of Athens (NTUA), 2016)
An extension of the Ritz-Galerkin method, based on finding approximations on a finite-dimensional manifold of functions (i.e., not a linear subspace) in the infinite-dimensional exact configuration space, will be presented. This new approach is particularly efficient in computing geometrically exact solutions for problems involving large rotations.
Konferenzveröffentlichung
Coupling atomistic models with continuous finite beam elements [Abstract]
(Institute of Structural Analysis and Antiseismic Research, School of Civil Engineering, National Technical University of Athens (NTUA), 2016)
Concurrent simulations of atomistic (discrete) and continuum models are one key to perform static calculations of large atomistic structures. Occurring ghost forces at the interfaces between discrete (atomistic) and continuous regions are a major challenge for the definition of such interfaces. The so called virtual projection method [1] is a class of force-based a/c schemes which reduce (or even avoid) ghost forces. This class of coupling schemes is able to deal with atomistic models consisting of bonded, multi-body ...
Dissertation
Synthese, Charakterisierung und koordinationschemische Untersuchung neuer Ferrocen-basierter Mono- und Diphosphidoliganden
(2016-08-29)
Die vorliegende Dissertation beschäftigt sich mit der Synthese der außerordentlich unterentwickelten Substanzklasse der sekundären Disphosphinoferrocene sowie der Auslotung ihrer koordinationschemischen Eigenschaften, speziell gegenüber den Übergangsmetallen Zirkonium und Nickel und dem Alkalimetall Lithium.