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Dissertation
Association of neighboring β-Strands to form the β-barrel structure of the voltage-dependent anion channel, human isoform 1 (hVDAC1) precedes membrane insertion and is largely driven by polar interactions between basic and acidic amino acid side-chains
(2020)
To date, all biophysical folding studies on β-barrel membrane proteins from outer membranes (OMPs) indicated a coupled mechanism of folding and membrane insertion. Most of these studies were performed with smaller OMPs from bacteria. Here we have investigated folding and insertion of a mitochondrial OMP, the voltage-dependent anion-selective channel (VDAC), human isoform 1 (hVDAC1). To examine whether folding and insertion are coupled for hVDAC1, the association of neighboring β-strands of the 19-stranded β-barrel ...
Dissertation
Energy Budget- and Temperature Index- based Calculations of Seasonal Mass Balances and Discharge in the Tropical Glacier Artesonraju and Artesoncocha Basin in the Cordillera Blanca,
Peru
(2020)
The core of the present Doctoral study deals with glacier simulations for calculating mass balance and discharge in the Artesonraju glacier and Artesoncocha basin, in the Cordillera Blanca (CB), Peru. For this purpose, two different models are used. One is an energy-model (EBM) which is physically based and uses energy fluxes measurements on the glaciers, whereas the other one is a temperature index model (TIM) which is empirical and uses mainly temperature and precipitation as its main input data.
An analysis of ...
Dissertation
Entkopplungsphänomene bei der Umsetzung institutionalisierter Managementkonzepte
(2020-08-06)
Die Arbeit widmet sich der Entkopplung bei mimetischem Isomorphismus, indem sie am besonderen Beispiel des Managementkonzepts der Lean Production verschiedene Entkopplungsphänomene offenlegt. Sie entwickelt darauf aufbauend ein Modell, das die Entkopplung bei mimetischem Isomorphismus als Prozess darstellt.
Dissertation
The tRNA binding protein Kti12 and its role in the regulation of Elongator complex
(2020-06-08)
[Summary] Kti12 is a conserved eukaryotic protein showing sequence homology to O-phosphoseryltRNA kinase (Pstk), which is required for the synthesis of selenocysteine tRNA. Saccharomyces cerevisiae Kti12 was originally discovered in a genetic screening for resistance against zymocin, a protein toxin produced by Kluyveromyces lactis. The cytotoxicity of zymocin lies in its anticodon nuclease activity, causing tRNA depletion and cell death in sensitive yeast cells. It recognizes and cleaves a particular wobble uridine ...
Dissertation
Behaviour Study of Grouted Connection for Offshore Wind Turbine Structures with Brittle Cement Based Grouts
(2020)
Researches show that the energy demand in the world is significantly increasing and climate change becomes a problematic issue, therefore, the interest in renewable energy is growing extremely fast. Offshore wind energy is one of the most effective renewable sources in Europe and other places in the world. One of the most important parts in the offshore foundation is the grouted connection as it is the first element to be designed in the design of the foundation structure of an offshore wind turbine because the ...
Dissertation
Crowd-Based Entrepreneurship
(2020)
The aim of this dissertation is to explore the innovation potential of crowdsourcing for entrepreneurship. The main focus is to discover how crowd-based infrastructures (i. e., crowdsourcing platforms and crowdfunding platforms) can support entrepreneurs in their innovation activities and how this new paradigm can be used to generate value for customers as well as actors of entrepreneurial ecosystems. The results of the dissertation show that crowdsourcing offers numerous opportunities to support entrepreneurs in ...
Dissertation
On the Cooperation of Groups in Social Dilemmas
(2020)
Die Menschheit steht vor zahlreichen Umweltproblemen wie dem Klimawandel, Luft- und Wasserverschmutzung, Biodiversitätsverlust und der Übernutzung natürlicher Ressourcen. All diese Probleme haben gemein, dass sie soziale Dilemmata darstellen und nur durch die Kooperation großer Gruppen gelöst werden können. Diese Dissertation bietet eine Analyse zur Kooperation von Gruppen in vier Studien. Die Arbeit besteht aus zwei Teilen. In Teil I werden zwei Laborexperimente präsentiert, in denen Entscheidungen von Individuen ...
Dissertation
Investigation of the functional synergy and involvement of different tRNA modifications in translational control
(2020-07-02)
Transfer RNAs are essential adapter molecules employed in the translational process and are highly modified all over their structure. Specific modification of the four canonical ribonucleotides (A, U, C, G) is accomplished by various proteins and/or protein complexes, ranging from simple isomerisations (e.g. Ψ) and methylations (e.g. m5C) up to complex chemical structures (e.g. mcm5s2U, ct6A). The functions of tRNA modifications are linked to the specific position and may influence translation by supporting the native ...
Dissertation
A new perspective to strongly-interacting lattice fermions in the framework of density functional theory
(2020)
Die in dieser Arbeit formulierte Theorie betrachtet das Vielteilchenproblem wechselwirkender Fermionen auf einem Gitter aus einem neuen Blickwinkel.
Dissertation
Antecedents, Interpretations and Consequences of Strategic Change: A Business Model Perspective
(2020-10-15)
Firms increasingly face challenges caused by changes in their environment like shifts in custom-er preferences, the development of new (digital) technologies, or threats by new, disruptive business models (BM). Firm survival and achieving long-term success often require a firm’s reaction to these challenges. Therefore, firms mostly engage in and initiate strategic change like business model innovation (BMI), a dynamic process that alters strategies, structures, and iden-tities and involves various actors. Due to the ...