The synthesis of glycerolipids starts with the acylation of lipid backbones. Two structurally different glycerolipids emerge in the cell: ether-lipids and ester-lipids. In the case of ether-lipids the first fatty acid is substituted with a fatty alcohol inside the peroxisome. By the characterization of the protein FARAT in this thesis, a key enzyme in etherlipid-synthesis was identified for D. discoideum. FARAT shows a peroxisomal localization and is in principle able to do two jobs. Firstly, it initiates the peroxisomal ...

Purpose: Previous studies revealed that around 75 percent of all start-ups fail at an early stage. One main reason for this tremendous failure rate is that entrepreneurs are typically confronted with high levels of uncertainty about the viability of their proposed business idea. Following this argumentation, entrepreneurial decision-making can be defined as complex decision-making problem under both risk and uncertainty. While risk includes quantifiable probabilities, uncertainty describes situations where neither ...

Vor dem Hintergrund einer noch wenig fortgeschrittenen Forschung zu Wirkfaktoren von Coaching, zielt diese Dissertation darauf ab, die in neueren Forschungsarbeiten skizzierten Forschungslücken hinsichtlich Coach-Verhalten und Kontextfaktoren zu schließen. Um den Blickwinkel auf relevante Kontextfaktoren zu erweitern, liegt der Fokus auf dem Verhalten von Coaches in zwei verschiedenen Arten von Kontexten: dem Beginn von Coaching-Prozessen (d.h. der Eingangsdiagnostik) und Coaching für Gründer*innen. Diese Dissertation ...

Die circadiane Uhr terrestrischer Organismen erlaubt die Anpassung von Physiologie und Verhalten an 24 h Rhythmen der Umwelt wie beispielsweise den täglichen Licht-Dunkel-Wechsel. Rhyparobia maderae wurde als Organismus zur Forschung an der inneren Uhr etabliert. Die circadiane Uhr der Madeira Schabe ist die akzessorische Medulla (AME) im optischen Lobus, welche von etwa 240 Neuronen innerviert wird. Diese Neuronen exprimieren und kolokalisieren auffällig viele Neuropeptide, die als Neuromodulatoren/Neurotransmitter ...

In 2009, our group published two stable N-heterocyclic carbenes (NHCs) with a 1,1'-ferrocenediyl backbone (fc), which formally exhibit a six-membered FeIIC2N2CII-heterocycle. The stabilization of the fcNHCs is favored by bulky N-substituents. So far neopentyl and 2-adamantyl have been used for this purpose - a bulky primary and secondary alkyl substituent. In contrast to other cyclic diaminocarbenes, the fcNHCs are capable of activating small molecules such as NH3 or CO. The reason for this remarkable ability is the ...

This study adopts a postcolonial approach to scrutinise the policies and practices of heritage preservation in Taipei City, Taiwan. Postcolonial theory provides an analytical framework that destabilises the dominating discourses of urban development from a subaltern perspective. It interrogates how ordinary people have the capacity to appropriate urban spaces through the practices of everyday life, thereby claiming their rights to the living environment. In this sense, I argue that urban heritage is a social construction. ...

The activities of humans have transformed the earth over the last decades. The transformation is estimated to increase further in response to the growing world population. This has caused many countries to devise means to utilize resources sustainably. Bio-economy is seen as a means to reduce the high reliance on fossil materials and ensure the provision of raw materials, energy and food to the increasing world population in a sustainable manner. However, the rising demands for biomass to produce bioenergy have relied ...

Computer science has evolved so much that it influences almost every part of human live. A particularly personal part of human live is the selection of a given name for a newborn baby. The name discovery service Nameling is our way to help expectant parents with this decision. It is a web service that helps parents to find a given name for their newborn baby. We want to further improve the user experience of Nameling by personalizing its name results for the current user. We deem this important, because the selection ...

Effektive rheologiemodifizierende Zusatzmittel sind aus der modernen Betontechnologie nicht mehr wegzudenken. Sei es der wirtschaftlichere, weil schnellere Einbau von fließfähigem Normalbeton oder die Herstellung von hoch- und ultrahochfesten Betonen; die so genannten Fließmittel spielen eine zentrale Rolle beim Einsatz und bei der Entwicklung zeitgemäßer, zementgebundener Baustoffe. Zur detaillierten Untersuchung der Wirkungsmechanismen wurde in dieser Arbeit eine Methode entwickelt, die die Beobachtung der ...

Every quantum system inevitably interacts with its environment. This is a fundamental requirement that allows us to control, measure and, in general, interact with quantum systems. In that respect, a quantum system's openness can be interpreted as prerequisite that enables quantum technologies in the first place. The latter are built to harness the intrinsic quantum mechanical behavior of quantum devices in order to build new, powerful technologies. However, a quantum system's openness also causes it to interact ...