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Dissertation
Nachweis und Analyse BamA-assoziierter Faltungsintermediate des OmpA durch ortsgerichtete Fluoreszenzspektroskopie
(2020-05)
Die Faltung und Insertion von Außenmembranproteinen (OMPs) in die Außenmembran von Gram negativen Bakterien ist für das Leben der Zellen essentiell und erfordert den konservierten β-barrel assembly machinery (BAM) Komplex. Zahlreiche Studien befassen sich mit der Aufklärung des dahinterstehenden Faltungsmechanismus von OMPs, doch bislang ist nur sehr wenig darüber bekannt. Daher steht der Faltungsmechanismus der spontanen Faltung und Insertion von OMPs wie OmpA und der Einfluss der BAM Hauptkomponente BamA darauf, ...
Dissertation
Optical Amplification in Disordered Waveguiding Systems
(2020)
Bei dem Phänomen der verstärkten Emission in ungeordneten Systemen handelt es sich um ein wiederentdecktes und über die letzten Jahrzehnte stark debattiertes Themengebiet in der Literatur. Diese Dissertation soll hierzu zwei experimentelle Ansätze bieten, wobei beide in der Lage sind, bei optischer Anregung entweder Random Lasing oder Verstärkte Spontane Emission zu zeigen.
In dieser Arbeit wird thermisch induzierte Faltenbildung (Wrinklebildung) als neuer Ansatz zur Herstellung von Streuzentren in wellenleitenden ...
Dissertation
Development of Energy use Profiles, Reduction Concepts, and Implementation of Renewable Energies in the Central Ugandan Pineapple Processing Chains
(2020-02)
Pineapples, like all fruits, are highly perishable and require either immediate consumption or preservation. To make them more stable and add value, four major processing methods are being employed in Uganda, i.e. drying, munaanansi (local drink), wine, and juice making. Energy is one of the main inputs required to achieve any of the processing methods. The aim of this research was to develop energy use profiles, gain insights into energy use reduction options, and to evaluate the applicability of renewable energies ...
Dissertation
Assessment of genetic diversity in local breeds
(2020-06)
The present study aimed at assessing genetic diversity in selected local livestock breeds in Northern Germany, and furthermore, examining some of the indices used in describing diversity in populations. The study begun with an assessment of genetic diversity in the German Angler (RVA) and Red-and-white dual-purpose (RDN) cattle breeds. Analyses of the RVA and RDN pedigrees, consisting of 93,078 and 184,358 records, respectively, revealed a number of Red Holstein (RH) sires that were influential in these breeds. Even ...
Dissertation
Association of neighboring β-Strands to form the β-barrel structure of the voltage-dependent anion channel, human isoform 1 (hVDAC1) precedes membrane insertion and is largely driven by polar interactions between basic and acidic amino acid side-chains
(2020)
To date, all biophysical folding studies on β-barrel membrane proteins from outer membranes (OMPs) indicated a coupled mechanism of folding and membrane insertion. Most of these studies were performed with smaller OMPs from bacteria. Here we have investigated folding and insertion of a mitochondrial OMP, the voltage-dependent anion-selective channel (VDAC), human isoform 1 (hVDAC1). To examine whether folding and insertion are coupled for hVDAC1, the association of neighboring β-strands of the 19-stranded β-barrel ...
Dissertation
Energy Budget- and Temperature Index- based Calculations of Seasonal Mass Balances and Discharge in the Tropical Glacier Artesonraju and Artesoncocha Basin in the Cordillera Blanca,
Peru
(2020)
The core of the present Doctoral study deals with glacier simulations for calculating mass balance and discharge in the Artesonraju glacier and Artesoncocha basin, in the Cordillera Blanca (CB), Peru. For this purpose, two different models are used. One is an energy-model (EBM) which is physically based and uses energy fluxes measurements on the glaciers, whereas the other one is a temperature index model (TIM) which is empirical and uses mainly temperature and precipitation as its main input data.
An analysis of ...
Dissertation
Algorithmic Reduction of Biochemical Reaction Networks
(2022-02-25)
The dynamics of species concentrations of chemical reaction networks are given by autonomous first-order ordinary differential equations. Singular perturbation methods allow the computation of approximate reduced systems that make explicit several time scales with corresponding invariant manifolds. This thesis presents:
1. An algorithmic approach for the computation of such reductions on solid analytical grounds. Required scalings are derived using tropical geometry. The existence of invariant manifolds is subject ...
Dissertation
Entkopplungsphänomene bei der Umsetzung institutionalisierter Managementkonzepte
(2020-08-06)
Die Arbeit widmet sich der Entkopplung bei mimetischem Isomorphismus, indem sie am besonderen Beispiel des Managementkonzepts der Lean Production verschiedene Entkopplungsphänomene offenlegt. Sie entwickelt darauf aufbauend ein Modell, das die Entkopplung bei mimetischem Isomorphismus als Prozess darstellt.
Dissertation
The tRNA binding protein Kti12 and its role in the regulation of Elongator complex
(2020-06-08)
[Summary] Kti12 is a conserved eukaryotic protein showing sequence homology to O-phosphoseryltRNA kinase (Pstk), which is required for the synthesis of selenocysteine tRNA. Saccharomyces cerevisiae Kti12 was originally discovered in a genetic screening for resistance against zymocin, a protein toxin produced by Kluyveromyces lactis. The cytotoxicity of zymocin lies in its anticodon nuclease activity, causing tRNA depletion and cell death in sensitive yeast cells. It recognizes and cleaves a particular wobble uridine ...
Dissertation
Behaviour Study of Grouted Connection for Offshore Wind Turbine Structures with Brittle Cement Based Grouts
(2020)
Researches show that the energy demand in the world is significantly increasing and climate change becomes a problematic issue, therefore, the interest in renewable energy is growing extremely fast. Offshore wind energy is one of the most effective renewable sources in Europe and other places in the world. One of the most important parts in the offshore foundation is the grouted connection as it is the first element to be designed in the design of the foundation structure of an offshore wind turbine because the ...