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S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic
(2018-03-21)
S-adenosyl-L-homocysteine (SAH) hydrolases (SAHases) are involved in the regulation of methylation reactions in many organisms and are thus crucial for numerous cellular functions. Consequently, their dysregulation is associated with severe health problems. The SAHase-catalyzed reaction is reversible and both directions depend on the redox activity of nicotinamide adenine dinucleotide (NAD+) as a cofactor. Therefore, nicotinamide cofactor biomimetics (NCB) are a promising tool to modulate SAHase activity. In the ...
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Water Quality in Surface Water: A Preliminary Assessment of Heavy Metal Contamination of the Mashavera River, Georgia
(2018-03-23)
Water quality contamination by heavy metal pollution has severe effects on public health. In the Mashavera River Basin, an important agricultural area for the national food system in Georgia (e.g., vegetable, dairy and wine production), water contamination has multiple influences on the regional and country-wide health. With new industrial activities in the region, sediment extraction, and discharge of untreated wastewater into the river, its tributaries and irrigation canals, a comprehensive study of water quality ...
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Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila
(2018-03-30)
Spindly was originally identified as a specific regulator of Dynein activity at the kinetochore. In early prometaphase, Spindly recruits the Dynein/Dynactin complex, promoting the establishment of stable kinetochore-microtubule interactions and progression into anaphase. While details of Spindly function in mitosis have been worked out in cultured human cells and in the C. elegans zygote, the function of Spindly within the context of an organism has not yet been addressed. Here, we present loss- and gain-of-function ...
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Exploring the Supply-Demand-Discrepancy of Sustainable Financial Products in Germany from a Financial Advisor’s Point of View
(2018-03-23)
Although retail investors’ interest in sustainable investment is constantly increasing, German credit unions and co-operative banks offer few sustainable financial products. The purpose of the study is to explore the current gap between supply and demand of sustainable financial investments in German retail banking from a financial advisor’s point of view. We use qualitative analysis of interviews with financial advisors based on a Grounded Theory approach with the aim to identify the key causation in the cause-effect ...
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Protein Phosphatase Sit4 Affects Lipid Droplet Synthesis and Soraphen A Resistance Independent of Its Role in Regulating Elongator Dependent tRNA Modification
(2018-07-11)
The protein phosphatase Sit4 has been shown to be required for lipogenesis and resistance against the acetyl-CoA carboxylase inhibitor soraphen A. Since Sit4 is also required for biosynthesis of Elongator dependent tRNA modifications such as 5-methoxycarbonylmethyluridine (mcm5U), we investigated the relevance of tRNA modifications in lipogenesis and soraphen A response. While sit4 and Elongator (elp3) mutants copy defects in mcm5U formation and stress sensitivity, they do not share soraphen A sensitivity and low ...
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Rainfall Prediction with AMSR–E Soil Moisture Products Using SM2RAIN and Nonlinear Autoregressive Networks with Exogenous Input (NARX) for Poorly Gauged Basins: Application to the Karkheh River Basin, Iran
(2018-07-23)
Accurate estimates of daily rainfall are essential for understanding and modeling the physical processes involved in the interaction between the land surface and the atmosphere. In this study, daily satellite soil moisture observations from the Advanced Microwave Scanning Radiometer–Earth Observing System (AMSR–E) generated by implementing the standard National Aeronautics and Space Administration (NASA) algorithm are employed for estimating rainfall, firstly, through the use of recently developed approach, SM2RAIN ...
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Extreme Ultraviolet to Visible Dispersed Single Photon Detection for Highly Sensitive Sensing of Fundamental Processes in Diverse Samples
(2018-05-23)
The detection of a single photon is the most sensitive method for sensing of photon emission. A common technique for single photon detection uses microchannel plate arrays combined with photocathodes and position sensitive anodes. Here, we report on the combination of such detectors with grating diffraction spectrometers, constituting a low-noise wavelength resolving photon spectroscopy apparatus with versatile applicability. We recapitulate the operation principle of such detectors and present the details of the ...
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Evaluation of Statistical-Downscaling/Bias-Correction Methods to Predict Hydrologic Responses to Climate Change in the Zarrine River Basin, Iran
(2018-04-20)
Modeling the hydrologic responses to future changes of climate is important for improving adaptive water management. In the present application to the Zarrine River Basin (ZRB), with the major reach being the main inflow source of Lake Urmia (LU), firstly future daily temperatures and precipitation are predicted using two statistical downscaling methods: the classical statistical downscaling model (SDSM), augmented by a trend-preserving bias correction, and a two-step updated quantile mapping (QM) method. The general ...
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Consumer Preferences for Local Food: Testing an Extended Norm Taxonomy
(2018-04-24)
Consumer attitudes toward consuming and buying locally produced food are well studied. By contrast, the topic of consumer preferences for local food, with a special emphasis on the role of norms, still lacks empirical evidence. To study the influence of norms and morals on the intention to buy local food products, a quantitative study (N = 327) focusing on external social and internalized moral norms was conducted using the constructs of the theory of planned behavior in combination with an extended norm taxonomy and ...
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Gott erzählen in biblischen Schriften des Alten Testaments
(2018)
In the Bible, God is one of many characters who is subject to the same principles of narrative modelling as the others. At the same time, however, God differs from other characters with regard to his transtextual attendance and the authority of his voice, which in turn influences the authority of the narrator’s voice. Biblical prophecy is conceptualized as a mediating voice between God and humans. In the narrative world, prophecy plays an important role in providing access to an otherwise inaccessible God. Moses, as ...