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Now showing items 1521-1530 of 1732
Dissertation
Molekulare Grundlagen der PKA-Lokalisierung durch A-Kinase-Ankerproteine
(2018-08-30)
A-Kinase-Ankerproteine (AKAPs) tragen maßgeblich zur Spezifität des ubiquitären cAMP-Signalweges bei. Dies geschieht unter anderem durch die Verankerung der cAMP-abhängigen Proteinkinase (PKA) an verschiedene Zellorganellen, wodurch die PKA-Effekte lokal und zeitlich begrenzt werden. AKAPs variieren erheblich in Größe und Struktur, zeigen aber als gemeinsames Strukturmotiv eine amphipathische Helix auf. Alle vier Isoformen der regulatorischen Untereinheit der PKA (PKA-R) bilden bei Dimerisierung eine hydrophobe ...
Dissertation
Variationelle Zeitdiskretisierungen höherer Ordnung der Konvektions-Diffusions-Reaktions-Gleichungen in zeitabhängigen Gebieten
(2016-08-11)
Wir betrachten zeitabhängige Konvektions-Diffusions-Reaktions-Gleichungen in zeitabhängigen Gebieten, wobei die Bewegung des Gebietsrandes bekannt ist. Die zeitliche Entwicklung des Gebietes wird durch die ALE-Formulierung behandelt, die die Nachteile der klassischen Euler-und Lagrange-Betrachtungsweisen behebt. Die Position des Randes und seine Geschwindigkeit werden dabei so in das Gebietsinnere fortgesetzt, dass starke Gitterdeformationen verhindert werden. Als Zeitdiskretisierungen höherer Ordnung werden stetige ...
Dissertation
Artificial micro RNA system in Dictyostelium discoideum
(2011-01-12)
Dictyostelium discoideum is a social amoeba that serves as a model system for RNA interference and related mechanisms. Its position between plants and animals enables evolutionary snapshot of mechanisms and protein machinery involved in investigated subjects. MiRNAs are small regulatory RNAs that are evolutionary conserved and present in animals, plants, viruses and some prokaryotes. They have roles in development, cell growth and differentiation, apoptosis and their miss-regulation is associated with many diseases ...
Dissertation
Capturing Emergent Semantics from Social Annotation Systems
(2013-02-26)
The ongoing growth of the World Wide Web, catalyzed by the increasing possibility of ubiquitous access via a variety of devices, continues to strengthen its role as our prevalent information and commmunication medium. However, although tools like search engines facilitate retrieval, the task of finally making sense of Web content is still often left to human interpretation. The vision of supporting both humans and machines in such knowledge-based activities led to the development of different systems which allow to ...
Dissertation
Interatomic Coulombic decay in noble gas clusters of varying sizes investigated by photon-induced (dispersed) fluorescence spectrometry
(2018-06-06)
The main topic of this thesis is to study experimentally an ultrafast and efficient non radiative mechanism – the well-known interatomic Coulombic decay (ICD) – in noble gas clusters by employing fluorescence spectrometry technique in combination with synchrotron radiation. Using Neon clusters as prototype systems, a special variety of ICD, termed resonant ICD (RICD), has been investigated by a selective excitation of one component of the cluster and for different mean cluster sizes. The first part of the thesis was ...
Aufsatz
Microsatellites from Fosterella christophii (Bromeliaceae) by de novo transcriptome sequencing on the Pacific Biosciences RS platform
(2016)
• Premise of the study: Microsatellite markers were developed in Fosterella christophii (Bromeliaceae) to investigate the genetic diversity and population structure within the F. micrantha group, comprising F. christophii, F. micrantha, and F. villosula. • Methods and Results: Full-length cDNAs were isolated from F. christophii and sequenced on a Pacific Biosciences RS platform. A total of 1590 high-quality consensus isoforms were assembled into 971 unigenes containing 421 perfect microsatellites. Thirty primer sets ...
Dissertation
Relatedness in Evidence Networks
(2014-10-10)
Einhergehend mit der Entwicklung und zunehmenden Verfügbarkeit des Internets hat sich die Art der Informationsbereitstellung und der Informationsbeschaffung deutlich geändert. Die einstmalige Trennung zwischen Publizist und Konsument wird durch kollaborative Anwendungen des sogenannten Web 2.0 aufgehoben, wo jeder Teilnehmer gleichsam Informationen bereitstellen und konsumieren kann. Zudem können Einträge anderer Teilnehmer erweitert, kommentiert oder diskutiert werden. Mit dem Social Web treten schließlich die ...
Aufsatz
Aphyllophoroid fungi in insular woodlands of eastern Ukraine
(2017-12-22)
Background
Fungi play crucial roles in ecosystems and are among the species-richest organism groups on Earth. However, knowledge on their occurrence lags behind the data for animals and plants. Recent analyses of fungal occurrence data from Western, Central and Northern Europe provided important insights into response of fungi to global warming. The consequences of the global changes for biodiversity on a larger geographical scale are not yet understood. Landscapes of Eastern Europe and particularly of eastern ...
Dissertation
Bridging Perspectives
(2016-09-29)
People’s ability to change their social and economic circumstances may be constrained by various forms of social, cultural and political domination. Thus to consider a social actor’s particular lifeworld in which the research is embedded assists in the understanding of how and why different trajectories of change occur or are hindered and how those changes fundamentally affect livelihood opportunities and constraints. In seeking to fulfill this condition this thesis adopted an actor-oriented approach to the study of ...
Dissertation
3D Simultaneous Inversion for Seismic Structure and Local Hypocenters in Germany under Consideration of Seismic Anisotropy in the Upper Mantel
(2010-10-20)
The main task of this work has been to investigate the effects of anisotropy onto the propagation of seismic waves along the Upper Mantle below Germany and adjacent areas.
Refraction- and reflexion seismic experiments proved the existence of Upper Mantle anisotropy and its influence onto the propagation of Pn-waves.
By the 3D tomographic investigations that have been done here for the crust and the upper mantle, considering the influence of anisotropy, a gap for the investigations in Europe has been closed.
These ...